Glaucoma, apoptose e sildenafil: compreensão de uma doença sem solução e uma possível abordagem de tratamento
Compreensão de uma doença sem solução e uma possível abordagem de tratamento
Palavras-chave:
Apoptose, glaucoma, células ganglionares da retinaResumo
Milhões de pacientes com glaucoma irão perder a visão, tornando-se uma necessidade
desenvolver terapias neuroprotetoras que possam ser usadas, em conjunção com
medicamentos hipotensores, para impedir a morte de células ganglionares da retina (CGR).
Recentes avanços na compreensão da fisiopatologia do glaucoma são um fator chave na
patogênese da neuropatia glaucomatosa. Com base nos achados em doenças semelhantes, a
hipótese de que melhorando o fluxo sanguíneo do nervo óptico da retina possa resultar em
uma proteção significativa nas CGR e prevenir a perda da visão no glaucoma. O sildenafil,
uma droga vasodilatadora que inibe PDE5, aumentando assim os níveis de cGMP e
prolongando seus efeitos, sendo que foi demonstrado melhorar a sobrevivência de várias
lesões degenerativas. Esta breve revisão resume alguns dos avanços mais importantes que
tiveram no entendimento sobre esta doença e um possível tratamento.
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