O extrato aquoso da casca de Caryocar brasiliense melhora a retração de feridas
DOI:
https://doi.org/10.35172/rvz.2022.v29.684Palavras-chave:
casca de pequi, fitoterapia, cicatrização de feridasResumo
Este estudo foi conduzido para verificar o efeito do extrato aquoso e da pomada à base de casca de Caryocar brasiliense sobre a retração de feridas em coelhos. Foram utilizados 12 coelhos Nova Zelândia Branco divididos em dois grupos e quatro lesões foram produzidas na região dorsal de cada animal. As lesões à direita foram tratadas com extrato aquoso (grupo 1) ou com a pomada (grupo 2) e as lesões à esquerda foram tratadas com solução salina 0,9% (grupo controle). Os níveis de colágeno e fibroblastos foram menores (P<0,05) em lesões tratadas com extrato aquoso, comparado com o grupo controle. Aos 7 e 14 dias após o procedimento, a retração das lesões era maior (P<0,05) quando tratadas com extrato aquoso e nas lesões tratadas com a pomada, a melhora ocorreu apenas no 7º dia, comparado com o tratamento controle. Concluiu-se que o extrato aquoso de casca de Caryocar brasiliense melhorou a retração de feridas por um período de tempo maior do que a pomada.
Referências
Mostafa WZ, Hegazy RA. Vitamin D and the skin: focus on a complex relationship: a review. J Adv Res 2015; 6(6): 793-804. https://dx.doi.org/10.1016/j.jare.2014.01.011 DOI: https://doi.org/10.1016/j.jare.2014.01.011
Lopez-Ojeda W, Pandey A, Alhajj M, Oakley AM. Anatomy, skin (integument). Treasure Island: StatPearls Publishing; 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441980/ Access on Sep 27, 2020.
Gonzales ACO, Costa TF, Andrade ZA, Medrado ARAP. Wound healing – a literature review. An Bras Dermatol 2016; 91(5): 614-620. https://doi.org/10.1590/abd1806-4841.20164741 DOI: https://doi.org/10.1590/abd1806-4841.20164741
Sorg H, Tilkorn D.J, Hager, S, Hauser, J, Mirastschijski, U. Skin wound healing: an update on the current knowledge and concepts. Eur Surg Res 2017; 58(1-2): 81-94. https://doi.org/10.1159/000454919 DOI: https://doi.org/10.1159/000454919
Negut I, Grumezescu V, Grumezescu AM. Treatment strategies for infected wounds. Molecules 2018; 23(9): 2392. https://dx.doi.org/10.3390/molecules23092392 DOI: https://doi.org/10.3390/molecules23092392
Dorai AA. Wound care with traditional, complementary and alternative medicine. Indian J Plast Surg 2012; 45(2): 418-424. https://dx.doi.org/10.4103/0970-0358.101331 DOI: https://doi.org/10.4103/0970-0358.101331
Kapp S, Miller C, Santamaria N. The quality of life of people who have chronic wounds and who self-treat. J Clin Nurs 2018; 27(1-2): 182-192. https://doi.org/10.1111/jocn.13870 DOI: https://doi.org/10.1111/jocn.13870
Oliveira AC, Rocha DM, Bezerra SMG, Andrade EMLR, Santos AMR, Nogueira LT. Quality of life of people with chronic wounds. Acta Paul Enferm 2019; 32(2): 194-201. http://dx.doi.org/10.1590/1982-0194201900027 DOI: https://doi.org/10.1590/1982-0194201900027
Lipsky BA, Hoey C. Topical antimicrobial therapy for treating chronic wounds. Clin Infect Dis 2009; 49(10): 1541-1549. https://doi.org/10.1086/644732 DOI: https://doi.org/10.1086/644732
Alberti LR, Vasconcellos LS, Petroianu A. Influence of local or systemic corticosteroids on skin wound healing resistance. Acta Cir Bras 2012; 27(4): 295-299. https://doi.org/10.1590/S0102-86502012000400003 DOI: https://doi.org/10.1590/S0102-86502012000400003
Ubbink DT, Santema TB, Stoekenbroek RM. Systemic wound care: a meta-review of Cochrane systematic reviews. Surg Technol Int 2014; 24(1): 99-111. PMID: 24700218
Shedoeva A, Leavesley D, Upton Z, Fan C. Wound healing and the use of medicinal plants. Evid-Based Complement Alternat Med 2019; 2019: 2684108. https://doi.org/10.1155/2019/2684108 DOI: https://doi.org/10.1155/2019/2684108
Zhang XN, Ma ZJ, Wang Y, Sun B, Guo X, Pan CQ, Chen LM. Angelica dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes. PlosOne 2017; 12(5): e0177862. https://doi.org/10.1371/journal.pone.0177862 DOI: https://doi.org/10.1371/journal.pone.0177862
Batista JS, Silva AE, Rodrigues CMF, Costa KMFM, Oliveira AF, Paiva ES et al. Avaliação da atividade cicatrizante do óleo de pequi (Caryocar coriaceum wittm) em lesões cutâneas produzidas experimentalmente em ratos. Arq Inst Biol 2010; 77(3): 441-447. DOI: https://doi.org/10.1590/1808-1657v77p4412010
Bezerra NKMS, Barros TL, Coelho NPMF. A ação do óleo de pequi (Caryocar brasiliense) no processo cicatricial de lesões cutâneas em ratos. Rev Bras Plantas Med 2015; 17(4): 875-880. (Supl. II). https://doi.org/10.1590/1983-084X/14_061 DOI: https://doi.org/10.1590/1983-084X/14_061
Oliveira JE, Martins DL, Dias MPR, Treichel TLE, Prado TD. Avaliação macroscópica da cicatrização de lesões de pele tratadas com extrato da folha de pequizeiro (Caryocar brasiliense). Braz J Dev 2020; 6(4): 17649-17659. https://doi.org/10.34117/bjdv6n4-075 DOI: https://doi.org/10.34117/bjdv6n4-075
Pires J, Cargnin ST, Costa SA, Sinhorin VDG, Damazo AS, Sinhorin AP et al. Healing of dermal wounds property of Caryocar brasiliense oil loaded polymeric lipid-core nanocapsules: formulation and in vivo evaluation. Eur J Pharm Sci 2020; 150: 105356. https://doi.org/10.1016/j.ejps.2020.105356 DOI: https://doi.org/10.1016/j.ejps.2020.105356
Magid AA, Voutquenne L, Moretti C, Long C, Lavaud C. Triterpenoid saponins from the fruits of Caryocar glabrum. J. Nat Prod 2006, 69(2): 196-205. https://doi.org/10.1021/np050336s DOI: https://doi.org/10.1021/np050336s
Magid AA, Voutquenne-Nazabadioko L, Harakat D, Moretti C, Lavaud C. Phenolic glycosides from the stem bark of Caryocar villosum and C. glabrum. J Nat Prod 2008; 71(5): 914-917. https://doi.org/10.1021/np800015p DOI: https://doi.org/10.1021/np800015p
Ascari J, Takahashi J.A, Boaventura MAD. The phytochemistry and biological aspects of Caryocaraceae family. Rev Bras Plantas Med 2013; 15(2): 293-308. https://doi.org/10.1590/S1516-05722013000200019 DOI: https://doi.org/10.1590/S1516-05722013000200019
Du JR, Long FY, Chen C. Research progress on natural triterpenoid saponins in the chemoprevention and chemotherapy of cancer. Enzyme 2014; 36(ch. 6): 95-130. https://doi.org/10.1016/b978-0-12-802215-3.00006-9 DOI: https://doi.org/10.1016/B978-0-12-802215-3.00006-9
Dinda B, Debnath S, Mohanta BC, Harigaya Y. Naturally occurring triterpenoid saponins. Chem Biodivers 2010; 7(10): 2327-2580. https://doi.org/10.1002/cbdv.200800070 DOI: https://doi.org/10.1002/cbdv.200800070
Kim YS, Cho IH, Jeong MJ, Jeong SJ, Nah SY, Cho YS et al. Therapeutic effect of total ginseng saponin on skin wound healing. J Ginseng Res 2011; 35(3): 360-367. https://dx.doi.org/10.5142/jgr.2011.35.3.360 DOI: https://doi.org/10.5142/jgr.2011.35.3.360
Si-ye MBM, Qiao-ling HMM, Lei SMM, Yan YBM, Cheng-cheng YBM, Wen YMM et al. Panax notoginseng saponins promotes cutaneous wound healing and suppresses scar formation in mice. J Cosmet Dermatol 2020; 19(2): 529-534. https://doi.org/10.1111/jocd.13042 DOI: https://doi.org/10.1111/jocd.13042
Agra LC, Ferro JNS, Barbosa FT, Barreto E. Triterpenes with healing activity: a systematic review. J Dermatol Treat 2015; 26(5): 465-470. https://doi.org/10.3109/09546634.2015.1021663 DOI: https://doi.org/10.3109/09546634.2015.1021663
Suktap C, Lee HK, Amnuaypol S, Suttisri R, Sukrong S. Wound healing effect of flavonoid glycosides from Afgekia mahidolae B.L. Burtt & Chermsir leaves. Rec Nat Prod 2018; 12(4): 391-396. http://doi.org/10.25135/rnp.39.17.10.166 DOI: https://doi.org/10.25135/rnp.39.17.10.166
Alexandru V, Gaspar A, Savin S, Toma A, Tatia R, Gille E. Phenolic content, antioxidant activity and effect on collagen synthesis of a traditional wound healing polyherbal formula. Stud Univ Vasile Goldis 2015; 25(1): 41-46. https://media.proquest.com/media/hms/ORIG/1/5BCYC?_s=J5UHRnoQY1VPpxyBoJV7SWi/orY%3D
Agar OT, Dikmen M, Ozturk N, Yilmaz MA, Temel H, Turkmenoglu FP. Comparative studies on phenolic composition, antioxidant, wound healing and cytotoxic activities of selected Achillea L. species growing in Turkey. Molecules 2015; 20(10): 17976-18000. https://dx.doi.org/10.3390/molecules201017976 DOI: https://doi.org/10.3390/molecules201017976
Dzialo M, Mierziak J, Korzun U, Preisner M, Szopa J, Kulma A. The potential of plant phenolics in prevention and therapy of skin disorders. Int J Mol Sci 2016; 17: 160. https://doi.org/10.3390/ijms17020160 DOI: https://doi.org/10.3390/ijms17020160
Zain MSC, Lee SY, Sarian MN, Fakurazi S, Shaari K. In vitro wound healing potential of flavonoid c-glycosides from oil palm (Elaeis guineensis Jacq.) leaves on 3T3 fibroblast cells. Antioxidants 2020; 9(4): 326. https://dx.doi.org/10.3390/antiox9040326 DOI: https://doi.org/10.3390/antiox9040326
Zhang XF, Wang HM, Song YL, Nie LH, Wang LF, Liu B et al. Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera. Bioorgan Med Chem Lett 2006; 16(4): 949-953. https://doi.org/10.1016/j.bmcl.2005.10.096 DOI: https://doi.org/10.1016/j.bmcl.2005.10.096
Hussain T, Tan B, Yin Y, Blachier F, Tossou MCB, Rahu N. Oxidative stress and inflammation: what polyphenols can do for us? Oxid Med Cell Longev 2016; 2016: 743279. https://dx.doi.org/10.1155/2016/7432797 DOI: https://doi.org/10.1155/2016/7432797
Vasconcelos AKP, Tomé AR, Pereira BS, Nunes-Pinheiro DCS. Avaliação dos unguentos à base de extratos hexânico ou etanólico das folhas de Momordica charantia L. sobre as lesões cutâneas experimentais em coelhos. Acta Sci Vet 2007, 35(1): 59-65. http://www.ufrgs.br/actavet/35-1/artigo705.pdf DOI: https://doi.org/10.22456/1679-9216.15815
Nunes PS, Albuquerque Junior RLC, Cavalcante DRR, Dantas MDM, Cardoso JC, Bezerra MS et al. Collagen-based films containing liposome-loaded usnic acid as dressing for dermal burn healing. Biomed Res Int 2011; 2011: 761593. https://doi.org/10.1155/2011/761593 DOI: https://doi.org/10.1155/2011/761593
Theoret C. Physiology of wound healing. In: Theoret C, Schumacher J, editor. Equine wound management. 3rd ed. San Francisco: John Wiley & Sons Inc.; 2017. Chapter 1. https://doi.org/10.1002/9781118999219.ch1 DOI: https://doi.org/10.1002/9781118999219
Tazima MFGS, Vicente YAMVA, Moriya T. Biologia da ferida e cicatrização. Medicina 2008; 41(3): 259-264. https://doi.org/10.11606/issn.2176-7262.v41i3p259-264 DOI: https://doi.org/10.11606/issn.2176-7262.v41i3p259-264
Chia CY, Medeiros AD, Corraes AMS, Manso JEF, Silva CSC, Takiya CM et al. Healing effect of andiroba-based emulsion in cutaneous wound healing via modulation of inflammation and transforming growth factor beta 3. Acta Cir Bras 2018; 33(11): 1000-1015. http://dx.doi.org/10.1590/s0102-865020180110000007 DOI: https://doi.org/10.1590/s0102-865020180110000007
Singh S, Young A, McNaught CE. The physiology of wound healing. Surgery 2017; 35(9): 473-477. https://doi.org/10.1016/j.mpsur.2017.06.004 DOI: https://doi.org/10.1016/j.mpsur.2017.06.004
Lingaraju GM, Krishna V, Hoskeri HJ, Pradeepa K, Venkatesh, Babu VPS. Wound healing promoting activity of stem bark extract of Semecarpus anacardium using rats. Nat Prod Res 2012; 26(24): 2344-2347. https://doi.org/10.1080/14786419.2012.656108 DOI: https://doi.org/10.1080/14786419.2012.656108
Maan P, Yadav KS, Yadav NP. Wound healing activity of Azadirachta indica A. Juss stem bark in mice. Pharmacogn Mag 2017; 13(suppl 2): S316-S320. https://doi.org/10.4103/0973-1296.210163 DOI: https://doi.org/10.4103/0973-1296.210163
Ugwu CN, Ezeibe EN, Nwobi CS, Eze CC, Evurani SA, Berebon PD et al. Preparation and evaluation of burns wound healing ointment base of leaves and stem bark of Anthocleista djalonensis (L) extract using animal model. Int J Pharm Edu Res 2019; 1(2): 29-36. https://doi.org/10.37021/ijper.v1i2.1 DOI: https://doi.org/10.37021/ijper.v1i2.1
Casao TRL, Pinheiro CG, Sarandy MM, Zanatta AC, Vilegas W, Novaes RD et al. Croton urucurana Baillon stem bark ointment accelerates the closure of cutaneous wounds in knockout IL-10 mice. J Ethnopharmacol 2020; 261: 113042. https://doi.org/10.1016/j.jep.2020.113042 DOI: https://doi.org/10.1016/j.jep.2020.113042
Hernandes L, Pereira LMS, Palazzo F, Mello JCP. Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin. Braz J Pharm Sci 2010; 46(3): 431-436. https://doi.org/10.1590/S1984-82502010000300005 DOI: https://doi.org/10.1590/S1984-82502010000300005
Eyarefe DO, Kuforiji DI, Jarikre TA, Emikpe BO Enhanced electroscalpel incisional wound healing potential of honey in Wistar rats. Int J Vet Sci Med 2017; 5(2): 128-134. https://doi.org/10.1016/j.ijvsm.2017.10.002 DOI: https://doi.org/10.1016/j.ijvsm.2017.10.002
Razika L, Thanina AC, Nadjiba CM, Narimen B, Mahdi DM, Karim A. Antioxidant and wound healing potential of saponins extracted from the leaves of Algerian Urtica dioica L. Pak J Pharm Sci 2017; 30(suppl 3): 1023-1029. Available at http://www.pjps.pk/wp-content/uploads/pdfs/30/3/Supplementary/16-SUP-695.pdf Access on 04 Out 2020.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.
