El extracto acuoso de la cáscara de Caryocar brasiliense mejora la retracción de heridas

Autores/as

  • Tales Dias do Prado Faculdad de Medicina Veterinaria, Universidad de Rio Verde, Rio Verde, GO. https://orcid.org/0000-0001-6273-8885
  • José Eduardo de Oliveira Faculdad de Medicina Veterinaria, Universidad de Rio Verde, Rio Verde, GO.
  • Maria Cristina de Oliveira Universidade de Rio Verde https://orcid.org/0000-0002-3024-2276
  • Tiago Luís Eilers Treichel Faculdad de Medicina Veterinaria, Universidad de Rio Verde, Rio Verde, GO.
  • Leonardo Souza Campos Faculdad de Medicina Veterinaria, Universidad de Rio Verde, Rio Verde, GO. https://orcid.org/0000-0003-0304-9929

DOI:

https://doi.org/10.35172/rvz.2022.v29.684

Palabras clave:

cáscara de, fitoterapia, cicatrización de heridas

Resumen

Este estudio fue conducido para verificar el efecto del extracto acuoso y de la pomada basada en cáscara de Caryocar brasiliense sobre la retracción de heridas en conejos. Fueron utilizados 12 conejos Nueva Zelanda Blanco divididos en dos grupos y cuatro lesiones fueron producidas en la región dorsal de cada animal. Las lesiones a la derecha fueron tratadas con extracto acuoso (grupo 1) o con la pomada (grupo 2) y las lesiones a la izquierda fueron tratadas con solución salina 0,9% (grupo control). Los niveles de colágeno y fibroblastos fueron menores (P<0,05) en lesiones tratadas con extracto acuoso, comparado con el grupo control. A los 7 y 14 días después del procedimiento, la retracción de las lesiones era mayor (P<0,05) cuando tratadas con extracto acuoso y en las lesiones tratadas con la pomada, la mejora ocurrió solamente el 7º día, comparado con el grupo control. Se concluyó que el extracto acuoso de la cáscara de Caryocar brasiliense mejoro la retracción de heridas por un período de tiempo mayor do que la pomada. 

Citas

Mostafa WZ, Hegazy RA. Vitamin D and the skin: focus on a complex relationship: a review. J Adv Res 2015; 6(6): 793-804. https://dx.doi.org/10.1016/j.jare.2014.01.011 DOI: https://doi.org/10.1016/j.jare.2014.01.011

Lopez-Ojeda W, Pandey A, Alhajj M, Oakley AM. Anatomy, skin (integument). Treasure Island: StatPearls Publishing; 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441980/ Access on Sep 27, 2020.

Gonzales ACO, Costa TF, Andrade ZA, Medrado ARAP. Wound healing – a literature review. An Bras Dermatol 2016; 91(5): 614-620. https://doi.org/10.1590/abd1806-4841.20164741 DOI: https://doi.org/10.1590/abd1806-4841.20164741

Sorg H, Tilkorn D.J, Hager, S, Hauser, J, Mirastschijski, U. Skin wound healing: an update on the current knowledge and concepts. Eur Surg Res 2017; 58(1-2): 81-94. https://doi.org/10.1159/000454919 DOI: https://doi.org/10.1159/000454919

Negut I, Grumezescu V, Grumezescu AM. Treatment strategies for infected wounds. Molecules 2018; 23(9): 2392. https://dx.doi.org/10.3390/molecules23092392 DOI: https://doi.org/10.3390/molecules23092392

Dorai AA. Wound care with traditional, complementary and alternative medicine. Indian J Plast Surg 2012; 45(2): 418-424. https://dx.doi.org/10.4103/0970-0358.101331 DOI: https://doi.org/10.4103/0970-0358.101331

Kapp S, Miller C, Santamaria N. The quality of life of people who have chronic wounds and who self-treat. J Clin Nurs 2018; 27(1-2): 182-192. https://doi.org/10.1111/jocn.13870 DOI: https://doi.org/10.1111/jocn.13870

Oliveira AC, Rocha DM, Bezerra SMG, Andrade EMLR, Santos AMR, Nogueira LT. Quality of life of people with chronic wounds. Acta Paul Enferm 2019; 32(2): 194-201. http://dx.doi.org/10.1590/1982-0194201900027 DOI: https://doi.org/10.1590/1982-0194201900027

Lipsky BA, Hoey C. Topical antimicrobial therapy for treating chronic wounds. Clin Infect Dis 2009; 49(10): 1541-1549. https://doi.org/10.1086/644732 DOI: https://doi.org/10.1086/644732

Alberti LR, Vasconcellos LS, Petroianu A. Influence of local or systemic corticosteroids on skin wound healing resistance. Acta Cir Bras 2012; 27(4): 295-299. https://doi.org/10.1590/S0102-86502012000400003 DOI: https://doi.org/10.1590/S0102-86502012000400003

Ubbink DT, Santema TB, Stoekenbroek RM. Systemic wound care: a meta-review of Cochrane systematic reviews. Surg Technol Int 2014; 24(1): 99-111. PMID: 24700218

Shedoeva A, Leavesley D, Upton Z, Fan C. Wound healing and the use of medicinal plants. Evid-Based Complement Alternat Med 2019; 2019: 2684108. https://doi.org/10.1155/2019/2684108 DOI: https://doi.org/10.1155/2019/2684108

Zhang XN, Ma ZJ, Wang Y, Sun B, Guo X, Pan CQ, Chen LM. Angelica dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes. PlosOne 2017; 12(5): e0177862. https://doi.org/10.1371/journal.pone.0177862 DOI: https://doi.org/10.1371/journal.pone.0177862

Batista JS, Silva AE, Rodrigues CMF, Costa KMFM, Oliveira AF, Paiva ES et al. Avaliação da atividade cicatrizante do óleo de pequi (Caryocar coriaceum wittm) em lesões cutâneas produzidas experimentalmente em ratos. Arq Inst Biol 2010; 77(3): 441-447. DOI: https://doi.org/10.1590/1808-1657v77p4412010

Bezerra NKMS, Barros TL, Coelho NPMF. A ação do óleo de pequi (Caryocar brasiliense) no processo cicatricial de lesões cutâneas em ratos. Rev Bras Plantas Med 2015; 17(4): 875-880. (Supl. II). https://doi.org/10.1590/1983-084X/14_061 DOI: https://doi.org/10.1590/1983-084X/14_061

Oliveira JE, Martins DL, Dias MPR, Treichel TLE, Prado TD. Avaliação macroscópica da cicatrização de lesões de pele tratadas com extrato da folha de pequizeiro (Caryocar brasiliense). Braz J Dev 2020; 6(4): 17649-17659. https://doi.org/10.34117/bjdv6n4-075 DOI: https://doi.org/10.34117/bjdv6n4-075

Pires J, Cargnin ST, Costa SA, Sinhorin VDG, Damazo AS, Sinhorin AP et al. Healing of dermal wounds property of Caryocar brasiliense oil loaded polymeric lipid-core nanocapsules: formulation and in vivo evaluation. Eur J Pharm Sci 2020; 150: 105356. https://doi.org/10.1016/j.ejps.2020.105356 DOI: https://doi.org/10.1016/j.ejps.2020.105356

Magid AA, Voutquenne L, Moretti C, Long C, Lavaud C. Triterpenoid saponins from the fruits of Caryocar glabrum. J. Nat Prod 2006, 69(2): 196-205. https://doi.org/10.1021/np050336s DOI: https://doi.org/10.1021/np050336s

Magid AA, Voutquenne-Nazabadioko L, Harakat D, Moretti C, Lavaud C. Phenolic glycosides from the stem bark of Caryocar villosum and C. glabrum. J Nat Prod 2008; 71(5): 914-917. https://doi.org/10.1021/np800015p DOI: https://doi.org/10.1021/np800015p

Ascari J, Takahashi J.A, Boaventura MAD. The phytochemistry and biological aspects of Caryocaraceae family. Rev Bras Plantas Med 2013; 15(2): 293-308. https://doi.org/10.1590/S1516-05722013000200019 DOI: https://doi.org/10.1590/S1516-05722013000200019

Du JR, Long FY, Chen C. Research progress on natural triterpenoid saponins in the chemoprevention and chemotherapy of cancer. Enzyme 2014; 36(ch. 6): 95-130. https://doi.org/10.1016/b978-0-12-802215-3.00006-9 DOI: https://doi.org/10.1016/B978-0-12-802215-3.00006-9

Dinda B, Debnath S, Mohanta BC, Harigaya Y. Naturally occurring triterpenoid saponins. Chem Biodivers 2010; 7(10): 2327-2580. https://doi.org/10.1002/cbdv.200800070 DOI: https://doi.org/10.1002/cbdv.200800070

Kim YS, Cho IH, Jeong MJ, Jeong SJ, Nah SY, Cho YS et al. Therapeutic effect of total ginseng saponin on skin wound healing. J Ginseng Res 2011; 35(3): 360-367. https://dx.doi.org/10.5142/jgr.2011.35.3.360 DOI: https://doi.org/10.5142/jgr.2011.35.3.360

Si-ye MBM, Qiao-ling HMM, Lei SMM, Yan YBM, Cheng-cheng YBM, Wen YMM et al. Panax notoginseng saponins promotes cutaneous wound healing and suppresses scar formation in mice. J Cosmet Dermatol 2020; 19(2): 529-534. https://doi.org/10.1111/jocd.13042 DOI: https://doi.org/10.1111/jocd.13042

Agra LC, Ferro JNS, Barbosa FT, Barreto E. Triterpenes with healing activity: a systematic review. J Dermatol Treat 2015; 26(5): 465-470. https://doi.org/10.3109/09546634.2015.1021663 DOI: https://doi.org/10.3109/09546634.2015.1021663

Suktap C, Lee HK, Amnuaypol S, Suttisri R, Sukrong S. Wound healing effect of flavonoid glycosides from Afgekia mahidolae B.L. Burtt & Chermsir leaves. Rec Nat Prod 2018; 12(4): 391-396. http://doi.org/10.25135/rnp.39.17.10.166 DOI: https://doi.org/10.25135/rnp.39.17.10.166

Alexandru V, Gaspar A, Savin S, Toma A, Tatia R, Gille E. Phenolic content, antioxidant activity and effect on collagen synthesis of a traditional wound healing polyherbal formula. Stud Univ Vasile Goldis 2015; 25(1): 41-46. https://media.proquest.com/media/hms/ORIG/1/5BCYC?_s=J5UHRnoQY1VPpxyBoJV7SWi/orY%3D

Agar OT, Dikmen M, Ozturk N, Yilmaz MA, Temel H, Turkmenoglu FP. Comparative studies on phenolic composition, antioxidant, wound healing and cytotoxic activities of selected Achillea L. species growing in Turkey. Molecules 2015; 20(10): 17976-18000. https://dx.doi.org/10.3390/molecules201017976 DOI: https://doi.org/10.3390/molecules201017976

Dzialo M, Mierziak J, Korzun U, Preisner M, Szopa J, Kulma A. The potential of plant phenolics in prevention and therapy of skin disorders. Int J Mol Sci 2016; 17: 160. https://doi.org/10.3390/ijms17020160 DOI: https://doi.org/10.3390/ijms17020160

Zain MSC, Lee SY, Sarian MN, Fakurazi S, Shaari K. In vitro wound healing potential of flavonoid c-glycosides from oil palm (Elaeis guineensis Jacq.) leaves on 3T3 fibroblast cells. Antioxidants 2020; 9(4): 326. https://dx.doi.org/10.3390/antiox9040326 DOI: https://doi.org/10.3390/antiox9040326

Zhang XF, Wang HM, Song YL, Nie LH, Wang LF, Liu B et al. Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera. Bioorgan Med Chem Lett 2006; 16(4): 949-953. https://doi.org/10.1016/j.bmcl.2005.10.096 DOI: https://doi.org/10.1016/j.bmcl.2005.10.096

Hussain T, Tan B, Yin Y, Blachier F, Tossou MCB, Rahu N. Oxidative stress and inflammation: what polyphenols can do for us? Oxid Med Cell Longev 2016; 2016: 743279. https://dx.doi.org/10.1155/2016/7432797 DOI: https://doi.org/10.1155/2016/7432797

Vasconcelos AKP, Tomé AR, Pereira BS, Nunes-Pinheiro DCS. Avaliação dos unguentos à base de extratos hexânico ou etanólico das folhas de Momordica charantia L. sobre as lesões cutâneas experimentais em coelhos. Acta Sci Vet 2007, 35(1): 59-65. http://www.ufrgs.br/actavet/35-1/artigo705.pdf DOI: https://doi.org/10.22456/1679-9216.15815

Nunes PS, Albuquerque Junior RLC, Cavalcante DRR, Dantas MDM, Cardoso JC, Bezerra MS et al. Collagen-based films containing liposome-loaded usnic acid as dressing for dermal burn healing. Biomed Res Int 2011; 2011: 761593. https://doi.org/10.1155/2011/761593 DOI: https://doi.org/10.1155/2011/761593

Theoret C. Physiology of wound healing. In: Theoret C, Schumacher J, editor. Equine wound management. 3rd ed. San Francisco: John Wiley & Sons Inc.; 2017. Chapter 1. https://doi.org/10.1002/9781118999219.ch1 DOI: https://doi.org/10.1002/9781118999219

Tazima MFGS, Vicente YAMVA, Moriya T. Biologia da ferida e cicatrização. Medicina 2008; 41(3): 259-264. https://doi.org/10.11606/issn.2176-7262.v41i3p259-264 DOI: https://doi.org/10.11606/issn.2176-7262.v41i3p259-264

Chia CY, Medeiros AD, Corraes AMS, Manso JEF, Silva CSC, Takiya CM et al. Healing effect of andiroba-based emulsion in cutaneous wound healing via modulation of inflammation and transforming growth factor beta 3. Acta Cir Bras 2018; 33(11): 1000-1015. http://dx.doi.org/10.1590/s0102-865020180110000007 DOI: https://doi.org/10.1590/s0102-865020180110000007

Singh S, Young A, McNaught CE. The physiology of wound healing. Surgery 2017; 35(9): 473-477. https://doi.org/10.1016/j.mpsur.2017.06.004 DOI: https://doi.org/10.1016/j.mpsur.2017.06.004

Lingaraju GM, Krishna V, Hoskeri HJ, Pradeepa K, Venkatesh, Babu VPS. Wound healing promoting activity of stem bark extract of Semecarpus anacardium using rats. Nat Prod Res 2012; 26(24): 2344-2347. https://doi.org/10.1080/14786419.2012.656108 DOI: https://doi.org/10.1080/14786419.2012.656108

Maan P, Yadav KS, Yadav NP. Wound healing activity of Azadirachta indica A. Juss stem bark in mice. Pharmacogn Mag 2017; 13(suppl 2): S316-S320. https://doi.org/10.4103/0973-1296.210163 DOI: https://doi.org/10.4103/0973-1296.210163

Ugwu CN, Ezeibe EN, Nwobi CS, Eze CC, Evurani SA, Berebon PD et al. Preparation and evaluation of burns wound healing ointment base of leaves and stem bark of Anthocleista djalonensis (L) extract using animal model. Int J Pharm Edu Res 2019; 1(2): 29-36. https://doi.org/10.37021/ijper.v1i2.1 DOI: https://doi.org/10.37021/ijper.v1i2.1

Casao TRL, Pinheiro CG, Sarandy MM, Zanatta AC, Vilegas W, Novaes RD et al. Croton urucurana Baillon stem bark ointment accelerates the closure of cutaneous wounds in knockout IL-10 mice. J Ethnopharmacol 2020; 261: 113042. https://doi.org/10.1016/j.jep.2020.113042 DOI: https://doi.org/10.1016/j.jep.2020.113042

Hernandes L, Pereira LMS, Palazzo F, Mello JCP. Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin. Braz J Pharm Sci 2010; 46(3): 431-436. https://doi.org/10.1590/S1984-82502010000300005 DOI: https://doi.org/10.1590/S1984-82502010000300005

Eyarefe DO, Kuforiji DI, Jarikre TA, Emikpe BO Enhanced electroscalpel incisional wound healing potential of honey in Wistar rats. Int J Vet Sci Med 2017; 5(2): 128-134. https://doi.org/10.1016/j.ijvsm.2017.10.002 DOI: https://doi.org/10.1016/j.ijvsm.2017.10.002

Razika L, Thanina AC, Nadjiba CM, Narimen B, Mahdi DM, Karim A. Antioxidant and wound healing potential of saponins extracted from the leaves of Algerian Urtica dioica L. Pak J Pharm Sci 2017; 30(suppl 3): 1023-1029. Available at http://www.pjps.pk/wp-content/uploads/pdfs/30/3/Supplementary/16-SUP-695.pdf Access on 04 Out 2020.

Publicado

2022-09-05

Cómo citar

1.
Dias do Prado T, de Oliveira JE, Oliveira MC de, Eilers Treichel TL, Souza Campos L. El extracto acuoso de la cáscara de Caryocar brasiliense mejora la retracción de heridas. RVZ [Internet]. 5 de septiembre de 2022 [citado 4 de diciembre de 2024];29:1-10. Disponible en: https://rvz.emnuvens.com.br/rvz/article/view/684

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