PROTEÍNAS DE FASE AGUDA EM CÃES: POSSÍVEIS APLICAÇÕES EM CIRURGIA

Autores

  • Camila Peres Rubio
  • Elizabeth Moreira dos Santos Schmidt

Palavras-chave:

proteína C-reativa, amilóide A sérico, pós operatório, soro

Resumo

As proteínas de fase aguda (PFA) são um grupo de proteínas do sangue que apresentam alteração nas suas concentrações em animais acometidos por infecções, inflamações, submetidos a trauma cirúrgico ou mesmo o estresse. A magnitude do aumento das proteínas de fase aguda está relacionada à intensidade do trauma cirúrgico. Como a concentração sanguínea das proteínas de fase aguda é diretamente proporcional ao grau de lesão tecidual e/ou de inflamação, espera-se que animais com de complicações pós-operatórias apresentem concentrações protéicas mais elevadas. Assim, as PFAs podem ser utilizadas como ferramentas para monitorar a intensidade da resposta inflamatória e como marcadores precoces de complicações pós-operatórias.

Referências

Murata H, Shimada N, Yoshioka M. Current research on acute phase proteins in veterinary diagnosis: an overview. Veterinary Journal. 2004; 168:28-40.

Petersen HH, Nielsen JP, Heegaard PMH. Application of acute phase protein measurements in veterinary clinical chemistry. Veterinary Research. 2004; 35:163-187.

Cerón JJ, Eckersall PD, Martinez-Subiela S. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Veterinary Clinical Pathology. 2005; 34:85-99.

Dabrowski R, Kostro K, Szczubial M. Concentrations of C-reactive protein, serum amyloid A, and haptoglobin in uterine arterial and peripheral blood in bitches with pyometra. Theriogenology. 2013; 80:494-497.

Gruys E, Toussaint MJM, Niewold TA, Koopmans SJ. Acute phase reaction and acute phase proteins. Journal Zhejiang University Science. 2005; 11:1045-1056.

Kjelgaard-Hansen M, Jacobsen S. Assay validation and diagnostic applications of major acute-phase protein testing in companion animals. Clinics in Laboratory Medicine. 2011; 31: 51-70.

Eckersall PD. Proteins, proteomics and the dysproteinemias. In: Kaneko JJ, Harvey JW, Bruss ML. Clinical biochemistry of domestic animals. 6a ed. Burlington: Academic Press; 2008. p.117-155.

Eckersall PD, Bell R. Acute phase proteins: biomarkers of infection and inflammation in veterinary medicine. The Veterinary Journal. 2010; 185:23-27.

Paltrinieri S. Early biomarkers of inflammation in dogs and cats: the acute phase proteins. Veterinary Research Communications. 2007; 31:125-129.

Suter M, Martinet O, Spertini F. Reduced acute phase response after laparoscopic total extraperitoneal bilateral hernia repair compared to open repair with the Stoppa procedure. Surgical Endoscopy And Other Interventional Techniques. 2002; 16:1214-1219.

Andrews DA, Reagan WJ, DeNicola DB. Plasma fibrinogen in recognizing equine inflammatorty disease. Continuing education for the practicing veterinarian. 1994; 16:1349-1357.

Jain NC. Schalm’s Veterinary Hematology. 4a ed. Philadelphia: Lea & Febiger; 1986.

Sutton RH, Johnstone M. The value of plasma fibrinogen estimations in dogs. A comparison with total leucocyte and neutrophil counts. The Journal of Small Animal Practice. 1977; 18:277-281.

Yuki M, Itoh H, Takase K. Serum alpha-1-acid glycoprotein concentration in clinically healthy puppies and adult dogs and in dogs with various diseases. Veterinary Clinical Pathology. 2010; 39:65-71.

Mold C, Rodriguez W, Rodic-Polic B, Du Clos TW. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc-gamma R. Journal of Immunology. 2002; 169:7019-7025.

Mortensen RF, Zhong W. Regulation of phagocytic leukocyte activities by C-reactive protein. Journal of Leukocyte Biology. 2000; 67:495-500.

Caspi D, Baltz ML, Snel F, Gruys E, Niv D, Batt RM, et al. Isolation and characterization of C-reactive protein from the dog. Immunology. 1984; 53:307-313.

Michelsen J, Heller J, Wills F, Noble GK. Effect of surgeon experience on postoperative plasma cortisol and C-reactive protein concentrations after ovariohysterectomy in the dog: a randomised trial. Australian Veterinary Journal. 2012; 90:474-478.

Kjelgaard-Hansen M, Strom H, Mikkelsen LF, Eriksen T, Jensen AL, Luntang-Jensen M. Canine serum C-reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery. Veterinary Clinical Pathology. 2013; 42:342-345.

Caspi D, Snel FW, Batt RM, Bennett D, Rutteman GR, Hartman EG, et al. C-reactive protein in dogs. American Journal Veterinary Research. 1987; 48:919-921.

Yamamoto S, Shida T, Miyaji S, Santsuka H, Fugise H, Mukawa K, et al. Changes in serum C-reactive protein levels in dogs with various disorders and surgical traumas. Veterinary Research Communication. 1993; 17:85-93.

Dabrowski R, Kostro K, Lisiecka U, Szczubial M, Krakowski L. Usefulness of C-reactive protein, serum amyloid A component, and haptoglobin determinations in bitches with pyometra for monitoring early post-ovariohysterectomy complications. Theriogenology. 2009; 72:471-476.

Dabrowski R, Wawron W, Kostro K. Changes in CRP, SAA and haptoglobin produced in response to ovariohysterectomy in health bitches and those with pyometra. Theriogenology. 2007; 67:321-327.

Serin G, Ulutas PA. Measurement of serum acute phase proteins to monitor postoperative recovery in anoestrus bitches after ovariohisterectomy. Veterinary Record. 2010; 166:20-22.

Burton SA, Honor DJ, Mackenzie AL, Eckersall PD, Markham RJ, Horney BS. C-reactive protein concentration in dogs with inflammatory leukograms. American Journal Veterinary Research. 1994; 55:613-618.

Conner JG, Eckersall PD, Fergusson J, Douglas TA. Acute phase response in the dog following surgical trauma. Research in Veterinary Science. 1988; 45:107-110.

Fournier T, Medjoubi NN, Porquet D. Alpha-1-acid glycoprotein. Biochimica et Biophysica Acta. 2000; 1482:157-171.

Yuki M, Itoh H, Tamura K, Nishii N, Takaseet K. Isolation, characterization and quantitation of canine alpha-1-acid glycoprotein. Veterinary Research Communication. 2008; 32:533-542.

Gahmberg CG, Anderson LC. Leukocyte surface origin of human alpha1-acid glycoprotein (oromucoid). Journal of Experimental Medicine. 1978; 148:507-521.

Hochepied T, Berger FG, Baumann H, Libert C. Alpha1-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine Growth Factor Reviews. 2003; 14:25-34.

Baumann H, Gauldie J. The acute phase response. Immunology Today. 1994; 15:74-80.

Ganrot K. Plasma protein response in experimental inflammation in the dog. Research Experimental Medicine. 1973; 161:251-261.

Hagman R. Serum α-1-acid glycoprotein concentrations in 26 dogs with pyometra. Veterinary Clinical Pathology. 2011; 40:52-59.

Hayashi S, Jinbo T, Iguchi T, Shimizu M, Shimada T, Nomura M, et al. A comparison of the concentrations of C-reactive protein and alpha 1-acid glycoprotein in the serum of young and adult dogs with acute inflamation. Veterinary Research Communication. 2001; 25:117-126.

Kuribayashi T, Shimizu M, Shimada T, Honjyo T, Yamamoto Y, Kuba K, et al. Alpha 1-acid glycoprotein (AAG) levels in healthy and pregnant beagle dogs. Experimentals Animals. 2003; 52:377–381.

Cerón JJ, Martínez-Subiela S. An automated spectrophotometric method for measuring canine ceruloplasmin in serum. Veterinary Research. 2004; 35:671- 679.

Helman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annual Review of Nutrition. 2002; 22:439-458.

Broadley C, Hoover RL. Ceruloplasmin reduces the adhesion and scavenges superoxide during the interaction of activated plomorphonuclear leukocytes with endothelial cells. American Journal of Pathology. 1989; 135:647-655.

Solter PF, Hoffmann WE, Hungerford LL, Siegel JP, Denis SHSt, Dorner JL. Haptoglobin and ceruloplasmin as determinants of inflammation in dogs. American Journal of Veterinary Research. 1991; 52:1738–1742.

Shim BS, Yoon CS, Oh SK, Lee TH, Kang YS. Studies on swine and canine serum haptoglobins. Biochimica et Biophysica Acta. 1971; 243:126-136.

Ceciliani F, Cerón JJ, Eckersall PD, Sauerwein H. Acute phase proteins in ruminants. Journal of Proteomics. 2012; 75:4207-4231.

Dobryszycka W. Biological functions of haptoglobin-new pieces toban old puzzle. Clinical Chemistry and Laboratory Medicine. 1997; 35:647-654.

Ebersole J, Cappelli D. Acute phase reactants in infectious and inflammatory diseases. Periodontology. 2000; 23:19-49.

Harvey JW, West CL. Prednisone-induced increases in serum alpha-2-globulin and haptoglobin concentration in dogs. Veterinary Pathology. 1987; 24:90-92.

Martínez-Subiela S, Ginel OJ, Cerón JJ. Effects of different glucocorticoid treatments on serum acute phase proteins in dogs. Veterinary Record. 2004; 154:814-817.

McGrotty YL, Arteaga A, Knottenbelt CM, Ramsey IK, Eckersall PD. Haptoglobin concentrations in dogs undergoing trilostane treatment for hyperadrenocorticism. Veterinary Clinical Pathology. 2005; 34:255-258.

Caldin M, Tasca S, Carli E, Bianchini S, Furlanello T, Martínez-Subiela S, et al. Serum acute phase protein concentrations in dogs with hyperadrenocorticism with and without concurrent inflammatory conditions. Veterinary Clinical Pathology. 2009; 38:63-68.

Couto CG, Cerón JJ, Parra MD, Martínez-Subiela S, Lazbik MC. Acute phase protein concentrations in retired racing Greyhounds. Veterinary Clinical Pathology. 2009; 38:219-223.

Urieli-Shoval S, Linke RP, Matzner Y. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states. Current Opinion in Hematology. 2000; 7:64-69.

Xu L, Badolato R, Murphy WJ, Longo DL, Anver M, Hales S, et al. A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion. The Journal of Immunology. 1995; 155:1184-1190.

Eckersall PD, Young FJ, Nolan AM, Knight CH, McComb C, Waterston MM, et al. Acute phase proteins in bovine milk in an experimental model of Staphylococcus aureus subclinical mastitis. Journal of Dairy Science. 2006; 89:1488-1501.

Lin Y, Michael W, Rajala MW, Berger JP, Moller DE, Barzilai N, et al. Hyperglycemia-induced production of acute phase reactants in adipose tissue. Journal of Biological Chemistry. 2001; 276:42077-42083.

Hughes D, Elliott DA, Washabau RJ, Kueppers F. Effects of age, sex, reproductive, and hospitalization on serum alpha 1-antitrypsin concentrations in dogs. American Journal Veterinary Research. 1995; 56:568-572.

Buttenschoen K, Buttenschoen DC, Berger D, Vasilescu C, Schafheutle S, Goeltenboth B, et al. Endotoxemia and acute-phase proteins in major abdominal surgery. The American Journal of Surgery. 2001; 181:36-43.

Eckersall PD, Conner JG, Harvie J. An immunoturbidimetric assay for canine C-reactive protein. Veterinary Research Communication. 1991; 15:17-24.

Kjelgaard-Hansen M, Kristensen AT, Jensen AL. Evaluation of a Commercially Available Enzyme-Linked Immunosorbent Assay (ELISA) for the Determination of C-Reactive Protein in Canine Serum. Journal of Veterinary Medicine Series A. 2003; 50:164-168.

Christensen M, Jacobsen S, Ichiyanagi T, Kjelgaard-Hansen M. Evaluation of an automated assay based on monoclonal anti-human serum amyloid A (SAA) antibodies for measurement of canine, feline, and equine SAA. The Veterinary Journal. 2012; 194:332-337.

Alves AE, Ribeiro APC, Di Filippo PA, Apparicio MF, Fagliari JJ, Vicente ERR. Leucogram and serum acute phase protein concentrations in queens submitted to conventional or videolaparoscopic ovariectomy. Arquivo Brasileiro de Medicina Veterinária e Zootecnia. 2010; 62:86-91.

Schmidt EMS, Lima AFM, Thomazini CM, Moraes LF, Campoy G, Garcia CZ, et al. Serum protein concentrations in female dogs submitted to ovariohysterectomy determined by means of SDS-PAGE electrophoresis. Veterinary Clinical Pathology. 2011; 40:607.

Downloads

Publicado

2022-04-26

Como Citar

1.
Rubio CP, Schmidt EM dos S. PROTEÍNAS DE FASE AGUDA EM CÃES: POSSÍVEIS APLICAÇÕES EM CIRURGIA. RVZ [Internet]. 26º de abril de 2022 [citado 22º de novembro de 2024];21(4):492-50. Disponível em: https://rvz.emnuvens.com.br/rvz/article/view/969

Edição

Seção

Artigos de Revisão

Artigos mais lidos pelo mesmo(s) autor(es)