ANTITUMOR EFFECT OF CURCUMIN IN CANINE AND HUMAN BLADDER UROTHELIAL CARCINOMA. LITERATURE REVIEW

Abstract

Recent studies have demonstrated differences in the prevention of natural products as antitumor therapeutic agents, evaluating the mechanism of action against neoplastic cells in human and veterinary medicine. Among them, turmeric, known as turmeric, stands out for its anti-inflammatory, anti-proliferative and pro-apoptotic properties. Curcumin is the main active compound of turmeric and has a useful antiproliferative and proapoptotic effect, already described in different neoplastic strains. In the urinary tract, the bladder is the organ most affected by neoplasms, 80% of which are malignant, including canine urothelial carcinoma (CUB), which corresponds to about 2% of all malignant tumors of the lower and upper urinary tract. Comment presented as a high-grade invasive neoplasm, located in the trigone and metastatic region. Their treatment is excision by machines, COX cyclooxygenase inhibitors, radiation therapy, or most of them. However, the location is often made impossible by the lesion. In addition, modern and recent studies seek that this similar neoplasm has different characteristics, as a human UB model therapeutic strategy. We discussed the use of curcumin in the therapy of bladder carcinoma, seeking to stimulate the development of more research on this topic.