REVISÃO DE LITERATURA: USO DE GABAPENTINA E PREGABALINA EM CÃES E GATOS NA DOR AGUDA E CRÔNICA
DOI:
https://doi.org/10.35172/rvz.2023.v30.1543Keywords:
gabapentinoids, Scale of Glasgow, Feline Grimace Scale, acute pain, chronic painAbstract
The use of gabapentinoids, especially gabapentin, is increasingly presente in the veterinary clinical routine. Initially its use was approved as na anticonvulsant and it the treatment of chronic neuropathic pain. In addition, it can be used for acute pain, starting its administration before the painful event and maintaining it in the post-event, fortunately with the multimodal analgesia and the reduction of stress in transport and handling of more irascible cats. To start your treatment in the case of pain, an adequate assessment is necessary to quantify from mild, moderate or intense pain in dogs and cats and, for that, must be used validated scales in both species that can be visual estimates, according to felt expressions or physical estimates, folllowing the example of a palpation in the affected region. This is the only way we can adjust doses, frequencies and effectiveness of administration, achieving the main objective of pain control.
References
Robertson K, Marshman LAG, Plummer D, Downs E. Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial. JAMA Neurol. 2019 Jan 1;76(1):28-34. doi: 10.1001/jamaneurol.2018.3077. DOI: https://doi.org/10.1001/jamaneurol.2018.3077
Maitra, Souvik et al. Perioperative gabapentin and pregabalin in cardiac surgery: a systematic review and meta-analysis. Rev bras anestesiol [online]. 2017, v. 67, n. 3 [citado 3 Out 2022], pp. 294-304. Disponível em: <https://doi.org/10.1016/j.bjane.2016.07.014>. ISSN 1806-907X. DOI: https://doi.org/10.1016/j.bjane.2016.07.014
Backonja M, Beydoun A, Edwards KR, et al. Gabapentin for the Symptomatic Treatment of Painful Neuropathy in Patients With Diabetes Mellitus: A Randomized Controlled Trial. JAMA. 1998;280(21):1831–1836. doi:10.1001/jama.280.21.1831 DOI: https://doi.org/10.1001/jama.280.21.1831
Wagner AE, Mich PM, Uhrig SR, Hellyer PW. Clinical evaluation of perioperative administration of gabapentin as an adjunct for postoperative analgesia in dogs undergoing amputation of a forelimb. J Am Vet Med Assoc. 2010 Apr 1;236(7):751-6. doi: 10.2460/javma.236.7.751. PMID: 20367041. DOI: https://doi.org/10.2460/javma.236.7.751
Gidal B, Billington R. New and emerging treatment options for neuropathic pain. American Journal Managed Care, v. 12, p. 269-278, 2006.
Crociolli GC. Gabapentin as adjuvant in the control of postoperative pain in female dogs undergoing mastectomy. 2014. 67 f. Dissertação (Mestrado em Ciências Agrárias) - Universidade do Oeste Paulista, Presidente Prudente, 2014.
Maneuf YP, Gonzalez MI, Sutton KS, Chung FZ, Pinnock RD, Lee K. Cellular and molecular action of the putative GABA-mimetic, gabapentin. Cell Mol Life Sci. 2003 Apr;60(4):742-50. doi: 10.1007/s00018-003-2108-x. PMID: 12785720. DOI: https://doi.org/10.1007/s00018-003-2108-x
Rose MA, Kam PC. Gabapentin: pharmacology and its use in pain management. Anaesthesia. 2002 May;57(5):451-62. doi: 10.1046/j.0003-2409.2001.02399.x. PMID: 11966555. DOI: https://doi.org/10.1046/j.0003-2409.2001.02399.x
Fonseca FG. Comparação de métodos analíticos na quantificação do teor de Gapapentina em diversas cápsulas de diversos laboratórios [Dissertação]. Portugal: Faculdade de Ciências e Tecnologias, Universidade do Algarve; 2014 [Citado 5 mai 2023];
Schmidt PC, Ruchelli G, Mackey SC, Carroll IR. Perioperative gabapentinoids: choice of agent, dose, timing, and effects on chronic postsurgical pain. Anesthesiology. 2013 Nov;119(5):1215-21. doi: 10.1097/ALN.0b013e3182a9a896. PMID: 24051389. DOI: https://doi.org/10.1097/ALN.0b013e3182a9a896
Fantoni DT. Tratamento da dor na clínica de pequenos animais. 1 ed. Rio de Janeiro: Elsevier; 2012. Antagonistas de receptores n-metil-d-aspartato (NMDA); p.277-289 e antidepressivos e anticonvulsivantes; p. 312-319.
Sontag SC, Belletini ST, Tramontin RS, Conti JB, Pachaly EMV, Quessada AM, Rodrigues NS, Pachaly JR. Utilização de gabapentina para manejo clínico de dor neuropática em cães – Relato de caso. Arq. Ciênc. Vet. Zool [Internet]. 2017 [citado 21 out 2022]; v. 20, n. 4, p. 221-231. DOI: https://doi.org/10.25110/arqvet.v20i4.2017.6401
Monteiro BP, Lascelles BDX, Murrell J, Robertson S, Steagall PVM and Wright B. WSAVA guidelines for the recognition, assessment and treatment of pain. J Small Anim Pract. 2022. https://doi.org/10.1111/jsap.13566 DOI: https://doi.org/10.1111/jsap.13566
Mathews K, Kronen PW, Lascelles D, Nolan A, Robertson S, Steagall PVM et al. Guidelines for Recognition, Assessment and Treatment of Pain: WSAVA Global Pain Council members and co-authors of this document. J small Anim Pract. 2014; 55(6). https://doi.org/10.1111/jsap.12200 DOI: https://doi.org/10.1111/jsap.12200
Grimm KA, Lamont LA, Tranquili WK, Greene SA, Robertson SA. Lumb & Jones – Anestesiologia e Analgesia em Veterinária. 5ª ed. Rio de Janeiro: Roca; 2017. Chap. 13, p.724-774.
Comassetto F. et al. Correlação entre as escalas analógica visual, de Glasgow, Colorado e Melbourne na avaliação de dor pós-operatória em cadelas submetidas à mastectomia total unilateral. Arq Bras Med Vet Zootec [online]. 2017, v. 69, n. 2 [citado 28 Out 2022], pp. 355-363. Disponível em: <https://doi.org/10.1590/1678-4162-9075>. DOI: https://doi.org/10.1590/1678-4162-9075
Reid J, Nolan AM, Hughes JML, Lascelles D, Pawson P, Scott EM. Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score. Anim Welfare. 2007; 16, pp. 97-104. DOI: https://doi.org/10.1017/S096272860003178X
Ramos, IHS. Analgesia não farmacológica no pós-operatório em pequenos animais [TCC] [Internet]. Gama (DF): Faculdade de Medicina Veterinária, Centro Universitário do Planalto Central Apparecido dos Santos; 2020 [citado 1 nov 2022] e disponível em: https://dspace.uniceplac.edu.br/handle/123456789/614.
Rialland P, Authier S, Guillot M, del Castillo JRE, Veilleux-Lemieux D, et al. Validation of Orthopedic Postoperative Pain Assessment Methods for Dogs: A Prospective, Blinded, Randomized, Placebo-Controlled Study. PLOS ONE [Internet]. 2012 [citado 18 Jan 2023] 7(11): e49480. https://doi.org/10.1371/journal.pone.0049480 DOI: https://doi.org/10.1371/journal.pone.0049480
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