Mycosis fungoides in a dog
DOI:
https://doi.org/10.35172/rvz.2006.v13.255Keywords:
lymphoma, mycosis fungoides, dog, immunohistochemistryAbstract
Mycosis fungoides is an uncommon kind of epitheliotropic lymphoma, originated from T
cells. The aim of this work is to describe a case of this disease in a male, mongrel, 5 years old
dog, that was brought to the Small Animal Clinic Service with alopecic, erythematous, non
pruriginous nodules with generalized distribution. The final diagnosis was made based on
clinical signs, cytology, histopathology and immunohistochemistry exam of the lesions. The
cells were positive for CD3 and negative for CD 79a, showing a T cell immunophenotype.
References
DAY, M.J. Immunophenotypic characterization of cutaneouslymphoid neoplasia in the dog
and cat. J. Comp. Pathol., v.112, p. 79-96, 1995.
DEBOER, D.J.; TURREL, J.M.; MOORE, P.F. Mycosis fungoides in a dog: demonstration of
T-cell specificity and response to radiotherapy. J. Am. Anim. Hosp. Med. Assoc., v.26, n.3,
p.566-572, 1990.
DUCLOS, D.D.; HARGIS, A.M. Canine epitheliotropic lymphoma limited to face and food
pads. Vet. Dermatol., v.7, p.243-246, 1996.
EDELSON, R.L. Cutaneous T-cell lymphoma: mycosis fungoides, Sézary syndrome and
other variants. J. Am. Acad. Dermatol., v.2, p.89-106, 1980.
FOURNEL-FLEURY, C.; PONCE, F.; FELMAN, P.; BLAVIER, A.; BONNEFONT, C.;
CHABANNE, L.; MARCHAL, T.; CADORE, J.L.; GOY-THOLLT, I.; LEDIEU, D.;
GHAERNATI, I.; MAGNOL, J.R. Canine T-cell lymphomas: a morphological,
immunological, and clinical study of 46 new cases. Vet. Pathol., v.39, p.92-109, 2002.
GROSS, T.L.; IHRKE, P.J.; WALDER, E.J.; AFFOLTER, V.R. Skin diseases of the dog
and cat: clinical and histopathologic diagnosis. Oxford: Blackwell, 2005. 932p.
HSU, S.M.; RAINE, L.; FANGER, H. Use of avidin-biotin-peroxidase complex (ABC) in
immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP)
procedures. J. Histochem. Cytochem., v.29, p.577-80, 1981.
JAFFE, E.S.; HARRIS, L.N.; STEIN, H.; VERDIMAN, J.W. World Health Organization
Classification of Tumors – Pathology an Genetics of Tumors of Haematopoietic and
Limphoid Tissues. Lyon: IARC Press, 2001. 351p.
LORIMIER, L.P. Updates on the management of canine epitheliotropic cutaneous T-cell
lymphoma. Vet. Clin. Small Anim. Pract., v. 36, p. 213-228, 2006.
MEUTEN, D.J. Tumors in domestic animals. 4. ed. Iowa: Blackwell, 2002. 788p.
MOORE, P.F.; AFFOLTER, V.K.; OLIVRY, T.; SCHRENZEL, M.D. The use of
immunological reagents in defining the pathogenesis of canine skin diseases involving
proliferation of leukocytes. In: KWOCHKA, K.W.; WILLEMSE, T.; VON TSCHARNER, C.
Advances in veterinary dermatology. Oxford: Butterworth Heinemann, 1998. p.77-94.
MOORE, P.F.; ROSSITO, P.V. Development of monoclonal antibodies to canine T cell
receptor complex (TCR/CD3) and their utilization in the diagnosis of T cell neoplasia. Vet.
Pathol., v. 30, p. 457, 1993.
PEREIRA, N.M.; PELETEIRO, M.C.; BRANCO, S.; COSTA, F.A. Linfoma maligno de
células T de localização cutânea (mycosis fungoides) em canídeo. Rev. Port. Cienc. Vet., v.
91, 518, p. 76-83, 1996.
SAMPAIO, S.A.P.; RIVITII, E.A. Dermatologia. 2. ed. São Paulo: Artes Médicas, 2001.
1156p.
SCOTT, D.W.; MILLER, W.H.; GRIFFIN, C.E. Muller & Kirk’s small animal
dermatology. 6. ed. Philadelphia: W.B. Saunders Company, 2001. 1528p.
WALTON, D.K. Canine epidermotropic lymphoma (mycosis fungoid and pagetoid
reticulosis). In: KIRK, R.W. Current veterinary therapy IX. Philadelphia: W.B. Saunders
Company, 1986. 609p.
WILCOCK, B.P.; YAGER, J.A. The behavior of epidermotropic lymphoma in twenty-fiv
dogs. Can. Vet. J., v.30, p.754-756, 1989.
and cat. J. Comp. Pathol., v.112, p. 79-96, 1995.
DEBOER, D.J.; TURREL, J.M.; MOORE, P.F. Mycosis fungoides in a dog: demonstration of
T-cell specificity and response to radiotherapy. J. Am. Anim. Hosp. Med. Assoc., v.26, n.3,
p.566-572, 1990.
DUCLOS, D.D.; HARGIS, A.M. Canine epitheliotropic lymphoma limited to face and food
pads. Vet. Dermatol., v.7, p.243-246, 1996.
EDELSON, R.L. Cutaneous T-cell lymphoma: mycosis fungoides, Sézary syndrome and
other variants. J. Am. Acad. Dermatol., v.2, p.89-106, 1980.
FOURNEL-FLEURY, C.; PONCE, F.; FELMAN, P.; BLAVIER, A.; BONNEFONT, C.;
CHABANNE, L.; MARCHAL, T.; CADORE, J.L.; GOY-THOLLT, I.; LEDIEU, D.;
GHAERNATI, I.; MAGNOL, J.R. Canine T-cell lymphomas: a morphological,
immunological, and clinical study of 46 new cases. Vet. Pathol., v.39, p.92-109, 2002.
GROSS, T.L.; IHRKE, P.J.; WALDER, E.J.; AFFOLTER, V.R. Skin diseases of the dog
and cat: clinical and histopathologic diagnosis. Oxford: Blackwell, 2005. 932p.
HSU, S.M.; RAINE, L.; FANGER, H. Use of avidin-biotin-peroxidase complex (ABC) in
immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP)
procedures. J. Histochem. Cytochem., v.29, p.577-80, 1981.
JAFFE, E.S.; HARRIS, L.N.; STEIN, H.; VERDIMAN, J.W. World Health Organization
Classification of Tumors – Pathology an Genetics of Tumors of Haematopoietic and
Limphoid Tissues. Lyon: IARC Press, 2001. 351p.
LORIMIER, L.P. Updates on the management of canine epitheliotropic cutaneous T-cell
lymphoma. Vet. Clin. Small Anim. Pract., v. 36, p. 213-228, 2006.
MEUTEN, D.J. Tumors in domestic animals. 4. ed. Iowa: Blackwell, 2002. 788p.
MOORE, P.F.; AFFOLTER, V.K.; OLIVRY, T.; SCHRENZEL, M.D. The use of
immunological reagents in defining the pathogenesis of canine skin diseases involving
proliferation of leukocytes. In: KWOCHKA, K.W.; WILLEMSE, T.; VON TSCHARNER, C.
Advances in veterinary dermatology. Oxford: Butterworth Heinemann, 1998. p.77-94.
MOORE, P.F.; ROSSITO, P.V. Development of monoclonal antibodies to canine T cell
receptor complex (TCR/CD3) and their utilization in the diagnosis of T cell neoplasia. Vet.
Pathol., v. 30, p. 457, 1993.
PEREIRA, N.M.; PELETEIRO, M.C.; BRANCO, S.; COSTA, F.A. Linfoma maligno de
células T de localização cutânea (mycosis fungoides) em canídeo. Rev. Port. Cienc. Vet., v.
91, 518, p. 76-83, 1996.
SAMPAIO, S.A.P.; RIVITII, E.A. Dermatologia. 2. ed. São Paulo: Artes Médicas, 2001.
1156p.
SCOTT, D.W.; MILLER, W.H.; GRIFFIN, C.E. Muller & Kirk’s small animal
dermatology. 6. ed. Philadelphia: W.B. Saunders Company, 2001. 1528p.
WALTON, D.K. Canine epidermotropic lymphoma (mycosis fungoid and pagetoid
reticulosis). In: KIRK, R.W. Current veterinary therapy IX. Philadelphia: W.B. Saunders
Company, 1986. 609p.
WILCOCK, B.P.; YAGER, J.A. The behavior of epidermotropic lymphoma in twenty-fiv
dogs. Can. Vet. J., v.30, p.754-756, 1989.
Additional Files
Published
2006-12-22
How to Cite
1.
Lahm Cardoso MJ, Torres Neto R, Amorim RL, E. Fabris V. Mycosis fungoides in a dog. RVZ [Internet]. 2006 Dec. 22 [cited 2024 May 16];13(2):137-43. Available from: https://rvz.emnuvens.com.br/rvz/article/view/255
Issue
Section
Case Reports
License
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.
