Type 1 von willebrand disease in st. Bernard dog
Clinical presentation and hemostasis profile
Keywords:
canine, congenital disease, factor VIII, bleeding, blood transfusionAbstract
The von Willebrand disease (vWD) results from a quantitative and / or qualitative deficiency
of von Willebrand factor (vWF). It is classified as a platelet- extrinsic defect, wherein the
hemostatic response failure is attributed to deficiency of a plasma factor required for normal
platelet function. This study aims to describe systematically the diagnosis of vWD type 1
exemplified in a case report of a dog treated at a veterinary teaching hospital due to intense
bilateral epistaxis.
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Schalm's Veterinary hematology. 6th ed. Ames: Wiley-Blackwel; 2010. p.612-8.
10. Stokol T, Trepanier L, Parry BW, Finnin BC. Pharmacokinetics of von Willebrand
factor and factor VIII in canine von Willebrand disease and haemophilia A. Res Vet
Sci. 1997;63:23-7.
11. Barr JW, McMichael M. Inherited disorders of hemostasis in dogs and cats. Top
Companion Anim Med. 2012; 27:53-8.
12. Brooks MB, Catalfamo JL. Current diagnostic trends in coagulation disorders among
dogs and cats. Vet Clin North Am Small Anim Pract. 2013;43:1349.
13. Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012;53;250-
6.
14. Mills J. Anemia. In: Day MJ, Kohn B. Manual of canine and feline haematology and
transfusion medicine. 2a ed. Gloucester: BSAVA; 2012. p.31-44.
15. Gibson G, Abrams-Ogg ACG. Canine transfusion medicine. In: Day MJ, Kohn B.
Manual of canine and feline haematology and transfusion medicine. 2a ed. Gloucester:
British Small Animal Veterinary Association; 2012. p.289-307
mucosal bleeding time in Greyhounds. Res Vet Sci. 2000;68:41-5.
2. Wardrop KJ. Clinical blood typing and crossmatching. In: Weiss DJ, Wardrop KJ.
Schalm's veterinary hematology. 6a ed. Ames: Wiley-Blackwell; 2010. p.1101-5.
3. Dalmolin ML. Avaliação da hemostasia em cães: fator de Von Willebrand e tempo de
protrombina e tromboplastina parcial ativada [dissertação]. Porto Alegre: Faculdade de
Veterinária, Universidade Federal do Rio Grande do Sul; 2015.
4. Mischke R. Optimization of coagulometric tests that incorporate human plasma for
determination of coagulation factor activities in canine plasma. Am J Vet Res.
2001;62:625-9.
5. Sadler JE. New concepts in Von Willebrand disease. Annu Rev Med. 2005;56:173-85.
6. Smith SA. The cell-based model of coagulation. J Vet Emerg and Crit Care. 2009;19:3-
10.
7. Riehl J, Okura M, Mignot E, Nishino S. Inheritance of von Willebrand's disease in a
colony of Doberman Pinschers. Am J Vet Res. 2000;61:115-20.
8. Johnstone I. Bleeding disorders in dogs: inherited disorders. In Pract. 2002;24:2.
9. Brooks MB, Catalfamo JL. von Willebrand Disease. In: Weiss DJ, Wardrop KJ.
Schalm's Veterinary hematology. 6th ed. Ames: Wiley-Blackwel; 2010. p.612-8.
10. Stokol T, Trepanier L, Parry BW, Finnin BC. Pharmacokinetics of von Willebrand
factor and factor VIII in canine von Willebrand disease and haemophilia A. Res Vet
Sci. 1997;63:23-7.
11. Barr JW, McMichael M. Inherited disorders of hemostasis in dogs and cats. Top
Companion Anim Med. 2012; 27:53-8.
12. Brooks MB, Catalfamo JL. Current diagnostic trends in coagulation disorders among
dogs and cats. Vet Clin North Am Small Anim Pract. 2013;43:1349.
13. Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012;53;250-
6.
14. Mills J. Anemia. In: Day MJ, Kohn B. Manual of canine and feline haematology and
transfusion medicine. 2a ed. Gloucester: BSAVA; 2012. p.31-44.
15. Gibson G, Abrams-Ogg ACG. Canine transfusion medicine. In: Day MJ, Kohn B.
Manual of canine and feline haematology and transfusion medicine. 2a ed. Gloucester:
British Small Animal Veterinary Association; 2012. p.289-307
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Published
2017-03-31
How to Cite
1.
Larruscaim Dalmolin M, Serina Lasta C, de Almeida Lacerda L, Camargo V, Loner Coutinho M, da Silva Vaz Junior I. Type 1 von willebrand disease in st. Bernard dog: Clinical presentation and hemostasis profile. RVZ [Internet]. 2017 Mar. 31 [cited 2024 Nov. 21];24(1):114-9. Available from: https://rvz.emnuvens.com.br/rvz/article/view/328
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Case Reports
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