Type 1 von willebrand disease in st. Bernard dog
Clinical presentation and hemostasis profile
Keywords:
canine, congenital disease, factor VIII, bleeding, blood transfusionAbstract
The von Willebrand disease (vWD) results from a quantitative and / or qualitative deficiency
of von Willebrand factor (vWF). It is classified as a platelet- extrinsic defect, wherein the
hemostatic response failure is attributed to deficiency of a plasma factor required for normal
platelet function. This study aims to describe systematically the diagnosis of vWD type 1
exemplified in a case report of a dog treated at a veterinary teaching hospital due to intense
bilateral epistaxis.
References
1. Sato I, Anderson GA, Parry BW. An interobserver and intraobserver study of buccal
mucosal bleeding time in Greyhounds. Res Vet Sci. 2000;68:41-5.
2. Wardrop KJ. Clinical blood typing and crossmatching. In: Weiss DJ, Wardrop KJ.
Schalm's veterinary hematology. 6a ed. Ames: Wiley-Blackwell; 2010. p.1101-5.
3. Dalmolin ML. Avaliação da hemostasia em cães: fator de Von Willebrand e tempo de
protrombina e tromboplastina parcial ativada [dissertação]. Porto Alegre: Faculdade de
Veterinária, Universidade Federal do Rio Grande do Sul; 2015.
4. Mischke R. Optimization of coagulometric tests that incorporate human plasma for
determination of coagulation factor activities in canine plasma. Am J Vet Res.
2001;62:625-9.
5. Sadler JE. New concepts in Von Willebrand disease. Annu Rev Med. 2005;56:173-85.
6. Smith SA. The cell-based model of coagulation. J Vet Emerg and Crit Care. 2009;19:3-
10.
7. Riehl J, Okura M, Mignot E, Nishino S. Inheritance of von Willebrand's disease in a
colony of Doberman Pinschers. Am J Vet Res. 2000;61:115-20.
8. Johnstone I. Bleeding disorders in dogs: inherited disorders. In Pract. 2002;24:2.
9. Brooks MB, Catalfamo JL. von Willebrand Disease. In: Weiss DJ, Wardrop KJ.
Schalm's Veterinary hematology. 6th ed. Ames: Wiley-Blackwel; 2010. p.612-8.
10. Stokol T, Trepanier L, Parry BW, Finnin BC. Pharmacokinetics of von Willebrand
factor and factor VIII in canine von Willebrand disease and haemophilia A. Res Vet
Sci. 1997;63:23-7.
11. Barr JW, McMichael M. Inherited disorders of hemostasis in dogs and cats. Top
Companion Anim Med. 2012; 27:53-8.
12. Brooks MB, Catalfamo JL. Current diagnostic trends in coagulation disorders among
dogs and cats. Vet Clin North Am Small Anim Pract. 2013;43:1349.
13. Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012;53;250-
6.
14. Mills J. Anemia. In: Day MJ, Kohn B. Manual of canine and feline haematology and
transfusion medicine. 2a ed. Gloucester: BSAVA; 2012. p.31-44.
15. Gibson G, Abrams-Ogg ACG. Canine transfusion medicine. In: Day MJ, Kohn B.
Manual of canine and feline haematology and transfusion medicine. 2a ed. Gloucester:
British Small Animal Veterinary Association; 2012. p.289-307
mucosal bleeding time in Greyhounds. Res Vet Sci. 2000;68:41-5.
2. Wardrop KJ. Clinical blood typing and crossmatching. In: Weiss DJ, Wardrop KJ.
Schalm's veterinary hematology. 6a ed. Ames: Wiley-Blackwell; 2010. p.1101-5.
3. Dalmolin ML. Avaliação da hemostasia em cães: fator de Von Willebrand e tempo de
protrombina e tromboplastina parcial ativada [dissertação]. Porto Alegre: Faculdade de
Veterinária, Universidade Federal do Rio Grande do Sul; 2015.
4. Mischke R. Optimization of coagulometric tests that incorporate human plasma for
determination of coagulation factor activities in canine plasma. Am J Vet Res.
2001;62:625-9.
5. Sadler JE. New concepts in Von Willebrand disease. Annu Rev Med. 2005;56:173-85.
6. Smith SA. The cell-based model of coagulation. J Vet Emerg and Crit Care. 2009;19:3-
10.
7. Riehl J, Okura M, Mignot E, Nishino S. Inheritance of von Willebrand's disease in a
colony of Doberman Pinschers. Am J Vet Res. 2000;61:115-20.
8. Johnstone I. Bleeding disorders in dogs: inherited disorders. In Pract. 2002;24:2.
9. Brooks MB, Catalfamo JL. von Willebrand Disease. In: Weiss DJ, Wardrop KJ.
Schalm's Veterinary hematology. 6th ed. Ames: Wiley-Blackwel; 2010. p.612-8.
10. Stokol T, Trepanier L, Parry BW, Finnin BC. Pharmacokinetics of von Willebrand
factor and factor VIII in canine von Willebrand disease and haemophilia A. Res Vet
Sci. 1997;63:23-7.
11. Barr JW, McMichael M. Inherited disorders of hemostasis in dogs and cats. Top
Companion Anim Med. 2012; 27:53-8.
12. Brooks MB, Catalfamo JL. Current diagnostic trends in coagulation disorders among
dogs and cats. Vet Clin North Am Small Anim Pract. 2013;43:1349.
13. Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012;53;250-
6.
14. Mills J. Anemia. In: Day MJ, Kohn B. Manual of canine and feline haematology and
transfusion medicine. 2a ed. Gloucester: BSAVA; 2012. p.31-44.
15. Gibson G, Abrams-Ogg ACG. Canine transfusion medicine. In: Day MJ, Kohn B.
Manual of canine and feline haematology and transfusion medicine. 2a ed. Gloucester:
British Small Animal Veterinary Association; 2012. p.289-307
Downloads
Published
2017-03-31
How to Cite
1.
Larruscaim Dalmolin M, Serina Lasta C, de Almeida Lacerda L, Camargo V, Loner Coutinho M, da Silva Vaz Junior I. Type 1 von willebrand disease in st. Bernard dog: Clinical presentation and hemostasis profile. RVZ [Internet]. 2017 Mar. 31 [cited 2024 Jul. 3];24(1):114-9. Available from: https://rvz.emnuvens.com.br/rvz/article/view/328
Issue
Section
Case Reports
License
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.
