Enfermedad de von willebrand de tipo 1 en un perro de la raza de san bernardo
Presentación clínica y el perfil de la hemostasia
Palabras clave:
canino, enfermedad congénita, factor VIII, sangrado, transfusión de sangreResumen
La enfermedad de von Willebrand (EvW) es el resultado de una deficiencia cuantitativa y/o
cualitativa del factor de von Willebrand (FvW). Esta clasificado como un defecto extrínseco
de las plaquetas, donde el fallo de respuesta hemostática se atribuye a la deficiencia de un
factor del plasma necesario para la función normal de las plaquetas. Este estudio tiene como
objetivo describir sistemáticamente el diagnóstico de la EvW tipo 1, tomando como ejemplo
el reporte de un caso de un perro que presenta intensa epistaxis bilateral tratado en el hospital
veterinario.
Citas
1. Sato I, Anderson GA, Parry BW. An interobserver and intraobserver study of buccal
mucosal bleeding time in Greyhounds. Res Vet Sci. 2000;68:41-5.
2. Wardrop KJ. Clinical blood typing and crossmatching. In: Weiss DJ, Wardrop KJ.
Schalm's veterinary hematology. 6a ed. Ames: Wiley-Blackwell; 2010. p.1101-5.
3. Dalmolin ML. Avaliação da hemostasia em cães: fator de Von Willebrand e tempo de
protrombina e tromboplastina parcial ativada [dissertação]. Porto Alegre: Faculdade de
Veterinária, Universidade Federal do Rio Grande do Sul; 2015.
4. Mischke R. Optimization of coagulometric tests that incorporate human plasma for
determination of coagulation factor activities in canine plasma. Am J Vet Res.
2001;62:625-9.
5. Sadler JE. New concepts in Von Willebrand disease. Annu Rev Med. 2005;56:173-85.
6. Smith SA. The cell-based model of coagulation. J Vet Emerg and Crit Care. 2009;19:3-
10.
7. Riehl J, Okura M, Mignot E, Nishino S. Inheritance of von Willebrand's disease in a
colony of Doberman Pinschers. Am J Vet Res. 2000;61:115-20.
8. Johnstone I. Bleeding disorders in dogs: inherited disorders. In Pract. 2002;24:2.
9. Brooks MB, Catalfamo JL. von Willebrand Disease. In: Weiss DJ, Wardrop KJ.
Schalm's Veterinary hematology. 6th ed. Ames: Wiley-Blackwel; 2010. p.612-8.
10. Stokol T, Trepanier L, Parry BW, Finnin BC. Pharmacokinetics of von Willebrand
factor and factor VIII in canine von Willebrand disease and haemophilia A. Res Vet
Sci. 1997;63:23-7.
11. Barr JW, McMichael M. Inherited disorders of hemostasis in dogs and cats. Top
Companion Anim Med. 2012; 27:53-8.
12. Brooks MB, Catalfamo JL. Current diagnostic trends in coagulation disorders among
dogs and cats. Vet Clin North Am Small Anim Pract. 2013;43:1349.
13. Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012;53;250-
6.
14. Mills J. Anemia. In: Day MJ, Kohn B. Manual of canine and feline haematology and
transfusion medicine. 2a ed. Gloucester: BSAVA; 2012. p.31-44.
15. Gibson G, Abrams-Ogg ACG. Canine transfusion medicine. In: Day MJ, Kohn B.
Manual of canine and feline haematology and transfusion medicine. 2a ed. Gloucester:
British Small Animal Veterinary Association; 2012. p.289-307
mucosal bleeding time in Greyhounds. Res Vet Sci. 2000;68:41-5.
2. Wardrop KJ. Clinical blood typing and crossmatching. In: Weiss DJ, Wardrop KJ.
Schalm's veterinary hematology. 6a ed. Ames: Wiley-Blackwell; 2010. p.1101-5.
3. Dalmolin ML. Avaliação da hemostasia em cães: fator de Von Willebrand e tempo de
protrombina e tromboplastina parcial ativada [dissertação]. Porto Alegre: Faculdade de
Veterinária, Universidade Federal do Rio Grande do Sul; 2015.
4. Mischke R. Optimization of coagulometric tests that incorporate human plasma for
determination of coagulation factor activities in canine plasma. Am J Vet Res.
2001;62:625-9.
5. Sadler JE. New concepts in Von Willebrand disease. Annu Rev Med. 2005;56:173-85.
6. Smith SA. The cell-based model of coagulation. J Vet Emerg and Crit Care. 2009;19:3-
10.
7. Riehl J, Okura M, Mignot E, Nishino S. Inheritance of von Willebrand's disease in a
colony of Doberman Pinschers. Am J Vet Res. 2000;61:115-20.
8. Johnstone I. Bleeding disorders in dogs: inherited disorders. In Pract. 2002;24:2.
9. Brooks MB, Catalfamo JL. von Willebrand Disease. In: Weiss DJ, Wardrop KJ.
Schalm's Veterinary hematology. 6th ed. Ames: Wiley-Blackwel; 2010. p.612-8.
10. Stokol T, Trepanier L, Parry BW, Finnin BC. Pharmacokinetics of von Willebrand
factor and factor VIII in canine von Willebrand disease and haemophilia A. Res Vet
Sci. 1997;63:23-7.
11. Barr JW, McMichael M. Inherited disorders of hemostasis in dogs and cats. Top
Companion Anim Med. 2012; 27:53-8.
12. Brooks MB, Catalfamo JL. Current diagnostic trends in coagulation disorders among
dogs and cats. Vet Clin North Am Small Anim Pract. 2013;43:1349.
13. Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012;53;250-
6.
14. Mills J. Anemia. In: Day MJ, Kohn B. Manual of canine and feline haematology and
transfusion medicine. 2a ed. Gloucester: BSAVA; 2012. p.31-44.
15. Gibson G, Abrams-Ogg ACG. Canine transfusion medicine. In: Day MJ, Kohn B.
Manual of canine and feline haematology and transfusion medicine. 2a ed. Gloucester:
British Small Animal Veterinary Association; 2012. p.289-307
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Publicado
2017-03-31
Cómo citar
1.
Larruscaim Dalmolin M, Serina Lasta C, de Almeida Lacerda L, Camargo V, Loner Coutinho M, da Silva Vaz Junior I. Enfermedad de von willebrand de tipo 1 en un perro de la raza de san bernardo: Presentación clínica y el perfil de la hemostasia. RVZ [Internet]. 31 de marzo de 2017 [citado 3 de julio de 2024];24(1):114-9. Disponible en: https://rvz.emnuvens.com.br/rvz/article/view/328
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Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.
