Tecido de granulação exuberante com presença de Candida sp no estômago de pôneis tratados com omeprazol
Palavras-chave:
úlcera gástrica, eqüino, inibidores da secreção ácida, candidíaseResumo
Relata-se caso de tecido de granulação exuberante recobrindo a superfície de úlceras gástricas
aglandulares espontâneas em dois pôneis hígidos submetidos a 31 dias de tratamento com omeprazol por
via oral, na dose de 4 mg kg-1. O exame histopatológico revelou úlcera com necrose tecidual, exsudato
fibrino-leucocitário e exuberante tecido de granulação. Adicionalmente, foram observadas estruturas
semelhantes a bactérias, pseudo-hifas e esporos de Candida sp. Apesar do quadro apresentado, os
animais permaneceram aparentemente sadios durante o tratamento. A lesão gástrica anteriormente
observada esteve ausente entre 75 e 90 dias após o término do tratamento com omeprazol.
Referências
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ANDREWS, F.M.; NADEAU, J.A. Clinical syndromes of gastric ulceration in foals and mature horses.
Equine vet. J. Suppl. 29, p.30-33, 1999.
DOUCET, M.Y. et al.. Efficacy of a paste formulation of omeprazole for the treatment of naturally
occurring gastric ulcers in training standardbred racehorses in Canada. Can. Vet. J., v.44, n.7, p.581-
585, 2003.
EL-ARAB, A.M.E. et al. Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in
mice. BMC Complement. Altern. Med., v.6, p.1-13, 2006.
GOENKA, M.K.M.D. et al. Candida overgrowth after treatment of duodenal ulcer: a comparison of
cimetidine, famotidine, and omeprazole. J. Clin. Gastroenterol., v.23, n.1, p.7-10, 1996.
HIRASAKI, S. et al. Benign gastric ulcer associated with Candida infection in a healthy adult. J.
Gastroenterol., v.34, n.6, p.688-693, 1999.
IRISH, J. et al. Honey has an antifungal effect against Candida species. Med. Mycol., v.44, n.3, p.289-
291, 2006.
HOOGERWERF, W.A.; PASRICHA, P. J.Agents used for control of gastric acidity and treatment of
peptic ulcers and gastroesophageal reflux disease. In: GILMAN, A.G.; LIMBIRD, L.E.; HARDMAN,
J.G. The pharmacological basis of therapeutics, 10th ed., New York: Mc Graw-Hill, 2001. p.1005-
1020.
KARMELI, Y. et al. Conventional dos of omeprazole alters gastric flora. Dig. Dis. Sci., v.40, n.9,
p.2070-2073, 1995.
KLINKENBERG-KNOL, E.C. et al. Long-term treatmente with omeprazole for refractory reflux
esophagitis: efficacy and safety. Ann. Intern. Med., v.121, n.3, p.161-167, 1994.
LARNER, A.J.; LENDRUM, R. Oesophageal candidiasis after omeprazole therapy. Gut, v.33, p.860-
861, 1992.
MacALLISTER, C.G. A review of medical treatment for peptic ulcer disease. Equine Vet. J., Suppl.
29, p.45-49, 1999.
MacALLISTER, C.G.; SANGIAB, S. Effect of ranitidine on healing of experimentally induced gastric
ulcers in ponies. Am. J. Vet. Res., v.54, n.7, p.1103-1107, 1993.
MARTINÉZ, A.C. et al. Risk factors for esophageal candidiasis. Eur. J. Microbiol. Infect. Dis., v.19,
n.2, p.96-100, 2000.
MURRAY, M.J. Ulceração gastroduodenal. In: REED, S.M.; BAYLY, W.M.. Medicina interna
eqüina. Rio de Janeiro: Guanabara Koogan, 2000. p.530-37.
MURRAY, M.J.; HART, J.; PARKER, G.A. Equine gastric ulcer syndrome: prevalence of gastric
lesions in asymptomatic foals. In: ANNUAL CONVENTION OF THE AMERICAM ASSOCIATION
EQUINE PRACTITIONERS, 33, 1987, New Orleans. Proceedings... New Orleans: AAEP, 1987.
p.769-776.
PRIM, F.J.P.; VILA, I. Tratamiento continuado com omeprazol y aparición de candidiasis orofaríngea.
Atención Primária, v.30, n.10, p.663-664, 2002.
PROPHET, E.B. et al. Laboratory methods in histotechnology. Washington: Armed Forces Institute
of Pathology, 1992. 264p.
SPEIRS, V.C. Exame clínico de eqüinos. Porto Alegre: Artmed, 1999. 366p.
VENNER, M.; LAUFFS, S.; DEEGEN, E. Treatment of gastric lesions in horses with pectin-lecithin
complex. Equine Vet. J., Suppl. 29, p.91-96, 1999.
v.94, n.11, p.706-707, 2002.
ANDREWS, F.M.; NADEAU, J.A. Clinical syndromes of gastric ulceration in foals and mature horses.
Equine vet. J. Suppl. 29, p.30-33, 1999.
DOUCET, M.Y. et al.. Efficacy of a paste formulation of omeprazole for the treatment of naturally
occurring gastric ulcers in training standardbred racehorses in Canada. Can. Vet. J., v.44, n.7, p.581-
585, 2003.
EL-ARAB, A.M.E. et al. Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in
mice. BMC Complement. Altern. Med., v.6, p.1-13, 2006.
GOENKA, M.K.M.D. et al. Candida overgrowth after treatment of duodenal ulcer: a comparison of
cimetidine, famotidine, and omeprazole. J. Clin. Gastroenterol., v.23, n.1, p.7-10, 1996.
HIRASAKI, S. et al. Benign gastric ulcer associated with Candida infection in a healthy adult. J.
Gastroenterol., v.34, n.6, p.688-693, 1999.
IRISH, J. et al. Honey has an antifungal effect against Candida species. Med. Mycol., v.44, n.3, p.289-
291, 2006.
HOOGERWERF, W.A.; PASRICHA, P. J.Agents used for control of gastric acidity and treatment of
peptic ulcers and gastroesophageal reflux disease. In: GILMAN, A.G.; LIMBIRD, L.E.; HARDMAN,
J.G. The pharmacological basis of therapeutics, 10th ed., New York: Mc Graw-Hill, 2001. p.1005-
1020.
KARMELI, Y. et al. Conventional dos of omeprazole alters gastric flora. Dig. Dis. Sci., v.40, n.9,
p.2070-2073, 1995.
KLINKENBERG-KNOL, E.C. et al. Long-term treatmente with omeprazole for refractory reflux
esophagitis: efficacy and safety. Ann. Intern. Med., v.121, n.3, p.161-167, 1994.
LARNER, A.J.; LENDRUM, R. Oesophageal candidiasis after omeprazole therapy. Gut, v.33, p.860-
861, 1992.
MacALLISTER, C.G. A review of medical treatment for peptic ulcer disease. Equine Vet. J., Suppl.
29, p.45-49, 1999.
MacALLISTER, C.G.; SANGIAB, S. Effect of ranitidine on healing of experimentally induced gastric
ulcers in ponies. Am. J. Vet. Res., v.54, n.7, p.1103-1107, 1993.
MARTINÉZ, A.C. et al. Risk factors for esophageal candidiasis. Eur. J. Microbiol. Infect. Dis., v.19,
n.2, p.96-100, 2000.
MURRAY, M.J. Ulceração gastroduodenal. In: REED, S.M.; BAYLY, W.M.. Medicina interna
eqüina. Rio de Janeiro: Guanabara Koogan, 2000. p.530-37.
MURRAY, M.J.; HART, J.; PARKER, G.A. Equine gastric ulcer syndrome: prevalence of gastric
lesions in asymptomatic foals. In: ANNUAL CONVENTION OF THE AMERICAM ASSOCIATION
EQUINE PRACTITIONERS, 33, 1987, New Orleans. Proceedings... New Orleans: AAEP, 1987.
p.769-776.
PRIM, F.J.P.; VILA, I. Tratamiento continuado com omeprazol y aparición de candidiasis orofaríngea.
Atención Primária, v.30, n.10, p.663-664, 2002.
PROPHET, E.B. et al. Laboratory methods in histotechnology. Washington: Armed Forces Institute
of Pathology, 1992. 264p.
SPEIRS, V.C. Exame clínico de eqüinos. Porto Alegre: Artmed, 1999. 366p.
VENNER, M.; LAUFFS, S.; DEEGEN, E. Treatment of gastric lesions in horses with pectin-lecithin
complex. Equine Vet. J., Suppl. 29, p.91-96, 1999.
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Publicado
2008-09-30
Como Citar
1.
de Oliveira Pinto J, de Souza MV, dos Santos Costa PR, Ribeiro Junior JI, do Carmo Lopes Moreira J. Tecido de granulação exuberante com presença de Candida sp no estômago de pôneis tratados com omeprazol. RVZ [Internet]. 30º de setembro de 2008 [citado 5º de novembro de 2024];15(3):449-55. Disponível em: https://rvz.emnuvens.com.br/rvz/article/view/397
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Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.
