Exuberant granulation tissue with presence of Candida sp in stomach of ponies treated with omeprazole
Keywords:
gastric ulcer, horse, gastric acid inhibitors, candidiasisAbstract
Two case of exuberant granulation tissue covering spontaneous noglandular gastric ulcers bed in two
ponies healthy orally fed 4 mg kg-1 of omeprazole during 31 days, are reported. The histopathological
examination of this tissue disclosed ulcers with tissue necrosis, fibrinous-leucocytary exudates, and
exuberant granulation tissue. Additionally, structures similar to bacteria, pseudo-hyphas and spores of
Candida sp were observed. Although the problem, the animals were apparently healthy during the
treatment. The gastric lesion previously observed was absent between 75 and 90 days the ending of the
treatment with omeprazole.
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LARNER, A.J.; LENDRUM, R. Oesophageal candidiasis after omeprazole therapy. Gut, v.33, p.860-
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MacALLISTER, C.G. A review of medical treatment for peptic ulcer disease. Equine Vet. J., Suppl.
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MacALLISTER, C.G.; SANGIAB, S. Effect of ranitidine on healing of experimentally induced gastric
ulcers in ponies. Am. J. Vet. Res., v.54, n.7, p.1103-1107, 1993.
MARTINÉZ, A.C. et al. Risk factors for esophageal candidiasis. Eur. J. Microbiol. Infect. Dis., v.19,
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VENNER, M.; LAUFFS, S.; DEEGEN, E. Treatment of gastric lesions in horses with pectin-lecithin
complex. Equine Vet. J., Suppl. 29, p.91-96, 1999.
v.94, n.11, p.706-707, 2002.
ANDREWS, F.M.; NADEAU, J.A. Clinical syndromes of gastric ulceration in foals and mature horses.
Equine vet. J. Suppl. 29, p.30-33, 1999.
DOUCET, M.Y. et al.. Efficacy of a paste formulation of omeprazole for the treatment of naturally
occurring gastric ulcers in training standardbred racehorses in Canada. Can. Vet. J., v.44, n.7, p.581-
585, 2003.
EL-ARAB, A.M.E. et al. Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in
mice. BMC Complement. Altern. Med., v.6, p.1-13, 2006.
GOENKA, M.K.M.D. et al. Candida overgrowth after treatment of duodenal ulcer: a comparison of
cimetidine, famotidine, and omeprazole. J. Clin. Gastroenterol., v.23, n.1, p.7-10, 1996.
HIRASAKI, S. et al. Benign gastric ulcer associated with Candida infection in a healthy adult. J.
Gastroenterol., v.34, n.6, p.688-693, 1999.
IRISH, J. et al. Honey has an antifungal effect against Candida species. Med. Mycol., v.44, n.3, p.289-
291, 2006.
HOOGERWERF, W.A.; PASRICHA, P. J.Agents used for control of gastric acidity and treatment of
peptic ulcers and gastroesophageal reflux disease. In: GILMAN, A.G.; LIMBIRD, L.E.; HARDMAN,
J.G. The pharmacological basis of therapeutics, 10th ed., New York: Mc Graw-Hill, 2001. p.1005-
1020.
KARMELI, Y. et al. Conventional dos of omeprazole alters gastric flora. Dig. Dis. Sci., v.40, n.9,
p.2070-2073, 1995.
KLINKENBERG-KNOL, E.C. et al. Long-term treatmente with omeprazole for refractory reflux
esophagitis: efficacy and safety. Ann. Intern. Med., v.121, n.3, p.161-167, 1994.
LARNER, A.J.; LENDRUM, R. Oesophageal candidiasis after omeprazole therapy. Gut, v.33, p.860-
861, 1992.
MacALLISTER, C.G. A review of medical treatment for peptic ulcer disease. Equine Vet. J., Suppl.
29, p.45-49, 1999.
MacALLISTER, C.G.; SANGIAB, S. Effect of ranitidine on healing of experimentally induced gastric
ulcers in ponies. Am. J. Vet. Res., v.54, n.7, p.1103-1107, 1993.
MARTINÉZ, A.C. et al. Risk factors for esophageal candidiasis. Eur. J. Microbiol. Infect. Dis., v.19,
n.2, p.96-100, 2000.
MURRAY, M.J. Ulceração gastroduodenal. In: REED, S.M.; BAYLY, W.M.. Medicina interna
eqüina. Rio de Janeiro: Guanabara Koogan, 2000. p.530-37.
MURRAY, M.J.; HART, J.; PARKER, G.A. Equine gastric ulcer syndrome: prevalence of gastric
lesions in asymptomatic foals. In: ANNUAL CONVENTION OF THE AMERICAM ASSOCIATION
EQUINE PRACTITIONERS, 33, 1987, New Orleans. Proceedings... New Orleans: AAEP, 1987.
p.769-776.
PRIM, F.J.P.; VILA, I. Tratamiento continuado com omeprazol y aparición de candidiasis orofaríngea.
Atención Primária, v.30, n.10, p.663-664, 2002.
PROPHET, E.B. et al. Laboratory methods in histotechnology. Washington: Armed Forces Institute
of Pathology, 1992. 264p.
SPEIRS, V.C. Exame clínico de eqüinos. Porto Alegre: Artmed, 1999. 366p.
VENNER, M.; LAUFFS, S.; DEEGEN, E. Treatment of gastric lesions in horses with pectin-lecithin
complex. Equine Vet. J., Suppl. 29, p.91-96, 1999.
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Published
2008-09-30
How to Cite
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de Oliveira Pinto J, de Souza MV, dos Santos Costa PR, Ribeiro Junior JI, do Carmo Lopes Moreira J. Exuberant granulation tissue with presence of Candida sp in stomach of ponies treated with omeprazole. RVZ [Internet]. 2008 Sep. 30 [cited 2024 Jul. 22];15(3):449-55. Available from: https://rvz.emnuvens.com.br/rvz/article/view/397
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