Tejido de granulación exuberante con la presencia de Candida sp en el estómago de ponis tratados con omeprazol
Palabras clave:
úlcera gástrica, caballo, inhibidores de la secreción ácida, candidiásicaResumen
Se relata caso de tejido de granulación exuberante por encima de los bordes de úlceras espontáneas
presentes en la porción aglandular del estómago de dos ponis sanos tratados con omeprazol, por via oral,
en la dosis de 4 mg kg-1 durante 31 días. El examen histopatológico de este tejido reveló úlceras con
necrosis tejidual, exudado fibrino-leucocitario y exuberante tejido de granulación. Además, fueron
observadas estructuras semejantes a bacterias, pseudohifas y esporas de Candida sp. A pesar del cuadro
presentado, los animales se mostraron aparentemente sanos durante el tratamiento. La lesión gástrica
anteriormente observada estuvo ausente entre los 75 y 90 días del término del tratamiento con
omeprazol.
Citas
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ANDREWS, F.M.; NADEAU, J.A. Clinical syndromes of gastric ulceration in foals and mature horses.
Equine vet. J. Suppl. 29, p.30-33, 1999.
DOUCET, M.Y. et al.. Efficacy of a paste formulation of omeprazole for the treatment of naturally
occurring gastric ulcers in training standardbred racehorses in Canada. Can. Vet. J., v.44, n.7, p.581-
585, 2003.
EL-ARAB, A.M.E. et al. Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in
mice. BMC Complement. Altern. Med., v.6, p.1-13, 2006.
GOENKA, M.K.M.D. et al. Candida overgrowth after treatment of duodenal ulcer: a comparison of
cimetidine, famotidine, and omeprazole. J. Clin. Gastroenterol., v.23, n.1, p.7-10, 1996.
HIRASAKI, S. et al. Benign gastric ulcer associated with Candida infection in a healthy adult. J.
Gastroenterol., v.34, n.6, p.688-693, 1999.
IRISH, J. et al. Honey has an antifungal effect against Candida species. Med. Mycol., v.44, n.3, p.289-
291, 2006.
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peptic ulcers and gastroesophageal reflux disease. In: GILMAN, A.G.; LIMBIRD, L.E.; HARDMAN,
J.G. The pharmacological basis of therapeutics, 10th ed., New York: Mc Graw-Hill, 2001. p.1005-
1020.
KARMELI, Y. et al. Conventional dos of omeprazole alters gastric flora. Dig. Dis. Sci., v.40, n.9,
p.2070-2073, 1995.
KLINKENBERG-KNOL, E.C. et al. Long-term treatmente with omeprazole for refractory reflux
esophagitis: efficacy and safety. Ann. Intern. Med., v.121, n.3, p.161-167, 1994.
LARNER, A.J.; LENDRUM, R. Oesophageal candidiasis after omeprazole therapy. Gut, v.33, p.860-
861, 1992.
MacALLISTER, C.G. A review of medical treatment for peptic ulcer disease. Equine Vet. J., Suppl.
29, p.45-49, 1999.
MacALLISTER, C.G.; SANGIAB, S. Effect of ranitidine on healing of experimentally induced gastric
ulcers in ponies. Am. J. Vet. Res., v.54, n.7, p.1103-1107, 1993.
MARTINÉZ, A.C. et al. Risk factors for esophageal candidiasis. Eur. J. Microbiol. Infect. Dis., v.19,
n.2, p.96-100, 2000.
MURRAY, M.J. Ulceração gastroduodenal. In: REED, S.M.; BAYLY, W.M.. Medicina interna
eqüina. Rio de Janeiro: Guanabara Koogan, 2000. p.530-37.
MURRAY, M.J.; HART, J.; PARKER, G.A. Equine gastric ulcer syndrome: prevalence of gastric
lesions in asymptomatic foals. In: ANNUAL CONVENTION OF THE AMERICAM ASSOCIATION
EQUINE PRACTITIONERS, 33, 1987, New Orleans. Proceedings... New Orleans: AAEP, 1987.
p.769-776.
PRIM, F.J.P.; VILA, I. Tratamiento continuado com omeprazol y aparición de candidiasis orofaríngea.
Atención Primária, v.30, n.10, p.663-664, 2002.
PROPHET, E.B. et al. Laboratory methods in histotechnology. Washington: Armed Forces Institute
of Pathology, 1992. 264p.
SPEIRS, V.C. Exame clínico de eqüinos. Porto Alegre: Artmed, 1999. 366p.
VENNER, M.; LAUFFS, S.; DEEGEN, E. Treatment of gastric lesions in horses with pectin-lecithin
complex. Equine Vet. J., Suppl. 29, p.91-96, 1999.
v.94, n.11, p.706-707, 2002.
ANDREWS, F.M.; NADEAU, J.A. Clinical syndromes of gastric ulceration in foals and mature horses.
Equine vet. J. Suppl. 29, p.30-33, 1999.
DOUCET, M.Y. et al.. Efficacy of a paste formulation of omeprazole for the treatment of naturally
occurring gastric ulcers in training standardbred racehorses in Canada. Can. Vet. J., v.44, n.7, p.581-
585, 2003.
EL-ARAB, A.M.E. et al. Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in
mice. BMC Complement. Altern. Med., v.6, p.1-13, 2006.
GOENKA, M.K.M.D. et al. Candida overgrowth after treatment of duodenal ulcer: a comparison of
cimetidine, famotidine, and omeprazole. J. Clin. Gastroenterol., v.23, n.1, p.7-10, 1996.
HIRASAKI, S. et al. Benign gastric ulcer associated with Candida infection in a healthy adult. J.
Gastroenterol., v.34, n.6, p.688-693, 1999.
IRISH, J. et al. Honey has an antifungal effect against Candida species. Med. Mycol., v.44, n.3, p.289-
291, 2006.
HOOGERWERF, W.A.; PASRICHA, P. J.Agents used for control of gastric acidity and treatment of
peptic ulcers and gastroesophageal reflux disease. In: GILMAN, A.G.; LIMBIRD, L.E.; HARDMAN,
J.G. The pharmacological basis of therapeutics, 10th ed., New York: Mc Graw-Hill, 2001. p.1005-
1020.
KARMELI, Y. et al. Conventional dos of omeprazole alters gastric flora. Dig. Dis. Sci., v.40, n.9,
p.2070-2073, 1995.
KLINKENBERG-KNOL, E.C. et al. Long-term treatmente with omeprazole for refractory reflux
esophagitis: efficacy and safety. Ann. Intern. Med., v.121, n.3, p.161-167, 1994.
LARNER, A.J.; LENDRUM, R. Oesophageal candidiasis after omeprazole therapy. Gut, v.33, p.860-
861, 1992.
MacALLISTER, C.G. A review of medical treatment for peptic ulcer disease. Equine Vet. J., Suppl.
29, p.45-49, 1999.
MacALLISTER, C.G.; SANGIAB, S. Effect of ranitidine on healing of experimentally induced gastric
ulcers in ponies. Am. J. Vet. Res., v.54, n.7, p.1103-1107, 1993.
MARTINÉZ, A.C. et al. Risk factors for esophageal candidiasis. Eur. J. Microbiol. Infect. Dis., v.19,
n.2, p.96-100, 2000.
MURRAY, M.J. Ulceração gastroduodenal. In: REED, S.M.; BAYLY, W.M.. Medicina interna
eqüina. Rio de Janeiro: Guanabara Koogan, 2000. p.530-37.
MURRAY, M.J.; HART, J.; PARKER, G.A. Equine gastric ulcer syndrome: prevalence of gastric
lesions in asymptomatic foals. In: ANNUAL CONVENTION OF THE AMERICAM ASSOCIATION
EQUINE PRACTITIONERS, 33, 1987, New Orleans. Proceedings... New Orleans: AAEP, 1987.
p.769-776.
PRIM, F.J.P.; VILA, I. Tratamiento continuado com omeprazol y aparición de candidiasis orofaríngea.
Atención Primária, v.30, n.10, p.663-664, 2002.
PROPHET, E.B. et al. Laboratory methods in histotechnology. Washington: Armed Forces Institute
of Pathology, 1992. 264p.
SPEIRS, V.C. Exame clínico de eqüinos. Porto Alegre: Artmed, 1999. 366p.
VENNER, M.; LAUFFS, S.; DEEGEN, E. Treatment of gastric lesions in horses with pectin-lecithin
complex. Equine Vet. J., Suppl. 29, p.91-96, 1999.
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Publicado
2008-09-30
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1.
de Oliveira Pinto J, de Souza MV, dos Santos Costa PR, Ribeiro Junior JI, do Carmo Lopes Moreira J. Tejido de granulación exuberante con la presencia de Candida sp en el estómago de ponis tratados con omeprazol. RVZ [Internet]. 30 de septiembre de 2008 [citado 22 de julio de 2024];15(3):449-55. Disponible en: https://rvz.emnuvens.com.br/rvz/article/view/397
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