PROSTATIC INTRAEPITHELIAL NEOPLASIA: MORPHOLOGICAL AND MOLECULAR ASPECTS

Authors

  • Marcela Marcondes Pinto Rodrigues
  • Giovana Wingeter Di Santis
  • Veridiana Maria Brianezi Dignani de Moura
  • Enio Pedone Bandarra
  • Renée Laufer Amorim

Keywords:

prostatic intraepithelial neoplasia (PIN), prostate, dog, immunohistochemistry

Abstract

Prostatic intraepithelial neoplasia (PIN) is a non-invasive prostatic lesion that shows genetic
abnormalities, cellular functions changes and phenotypic invasive cancer pattern.
Histopathological exam shows histo and cytological changes in pre existing ducts and acines,
mostly in a multifocal way. The lesion can be classified as low grade PIN (LGPIN) or high
grade PIN (HGPIN). Morphological aspects, including basal membrane rupture, higher
proliferative index and micro vascular density are suggestive that HGPIN is an intermediate
stage between normal epithelium and carcinoma.

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Published

2023-01-11

How to Cite

1.
Rodrigues MMP, Santis GWD, Moura VMBD de, Bandarra EP, Amorim RL. PROSTATIC INTRAEPITHELIAL NEOPLASIA: MORPHOLOGICAL AND MOLECULAR ASPECTS. RVZ [Internet]. 2023 Jan. 11 [cited 2024 May 15];17(1):19-25. Available from: https://rvz.emnuvens.com.br/rvz/article/view/1209

Issue

Vol. 17 No. 1 (2010)

Section

Review Articles

License

Licença Creative Commons
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.

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