Bone marrow changes and the importance of the myelogram in diagnosing canine monocytics ehrlichiosis

A review

Authors

  • Marília Salgado Caxito
  • Fernanda Panseri Rodrigues
  • Isis Indaiara Gonçalves Granjeiro Taques
  • Daniel Moura de Aguiar
  • Regina Kiomi Takahira
  • Antônio Carlos Paes

DOI:

https://doi.org/10.35172/rvz.2018.v25.37

Keywords:

Ehrlichia canis, myelogram, hematopoiesis, precursor cells, immune-mediated process

Abstract

Canine Monocytic Ehrlichiosis (CME) is a multisystemic disease with high incidence among dogs. However, its pathogenesis has not been fully elucidated. Plasma cells and lymphoplasmacytic infiltrates are observed in most organs of infected animals, including bone marrow. These infiltrates suggest that most of the pathological lesions identified in the chronic phase may be a consequence of the inflammatory process initiated at the beginning of the infection. This work aims to highlight the importance of the bone marrow evaluation of dogs with CME. A better understanding of the medullary changes in the acute phase could help clarifying the origin of clinical signs observed in the chronic phase. More studies are needed to verify whether the pathogenesis of CME is related to either the immune-mediated processes or the direct aggressions of Ehrlichia canis in precursor cells. Understanding the pathophysiological mechanisms of E. canis will improvement both current therapeutic strategies as well as the prognosis of severely affected animals.

Author Biographies

Marília Salgado Caxito

Mestranda em Medicina Veterinária, FMVZ, UNESP – Botucatu, SP

Fernanda Panseri Rodrigues

Médica Veterinária Residente do Laboratório Clínico Veterinário, Departamento de Clínica Veterinária, FMVZ, UNESP – Botucatu, SP.

Isis Indaiara Gonçalves Granjeiro Taques

Doutoranda em Ciências Veterinárias, FAMEVZ, Universidade Federal do Mato Grosso – Cuiabá, MT.

Daniel Moura de Aguiar

Docente, Departamento de Clínica Médica Veterinária, FAMEVZ, Universidade Federal do Mato Grosso, Cuiabá, MT.

Regina Kiomi Takahira

Docente, Departamento de Clínica Veterinária, FMVZ, UNESP – Botucatu, SP

Antônio Carlos Paes

Docente, Departamento de Higiene Veterinária e Saúde Pública, FMVZ, UNESP – Botucatu, SP

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Published

2018-12-04

How to Cite

1.
Caxito MS, Rodrigues FP, Taques IIGG, Aguiar DM de, Takahira RK, Paes AC. Bone marrow changes and the importance of the myelogram in diagnosing canine monocytics ehrlichiosis: A review. RVZ [Internet]. 2018 Dec. 4 [cited 2024 May 12];25(1):61-6. Available from: https://rvz.emnuvens.com.br/rvz/article/view/37

Issue

Vol. 25 No. 1 (2018)

Section

Review Articles

License

Licença Creative Commons
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.

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