POTENCIAL DE LA DESLORELINA COMO AGENTE INDUCTOR DE LA OVULACIÓN EN VACAS PRIMÍPARAS Bos taurus indicus EN LA INSEMINACIÓN ARTIFICIAL EN TIEMPO FIJO
Palabras clave:
Deslorelina intramuscular, IATF, protocolo hormonal, bovino, primíparasResumen
El objetivo del estudio ha sido verificar la eficiencia de la deslorelina (DES) como inductora
de la ovulación en protocolos de inseminación artificial en tiempo fijo (IATF) sobre las tasas
de preñez (TP) en vacas primíparas Bos taurus indicus. Se han utilizado 176 animales,
distribuidos en tres grupos: GNDES (Grupo No DES; n= 59), que recibió en el día 0 (d0) un
dispositivo intra vaginal con 0,558 g de progesterona (P4) + 2,0 mg de benzoato de estradiol
(BE) (IM); en el d8 remoción de la P4 + 0,5 mg de cipionato de estradiol (CE) + 150 mg de
cloprostenol + 400 UI de gonadotrofina coriónica equina (eCG); en el d10 fue ejecutada la
IATF; GDES (Grupo DES; n=60) el mismo que GNDES pero 1,0 mg (IM) de DES en el
momento de la IATF; GDES6 (Grupo Deslorelina 6 horas); n=57) el mismo que GDES, con
la diferencia que la DES ha sido aplicada con 6 horas de antelación relación a la IATF. Los
datos han sido sometidos a un análisis estadístico, a través del Programa SAS (2014). El
estudio resultó en tasa de preñez (TP) en la IATF y al final del ciclo estral, respectivamente
para GNDES, GDES y GDES6 en 40,6; 53,3; 43,8 % y 72,9; 81,7; 70,2 %. Concluyese que
la DES proporcionó en números absolutos un indicativo de mejoría en la TP y en la IATF en
los grupos tratados frente al controle; el ECC, días abiertos y el status reproductivo (anestro o
ciclicidad) no influenciaron la TP ni la IATF, ni a los 60 días ni al final del ciclo estral o
periodo de celo.
Citas
1. Lee MS, Rahman MS, Kwon WS, Chung HJ, Yang BS, Pang MG. Efficacy of four
synchronization protocols on the estrus behavior and conception in native Korean cattle
(Hanwoo). Theriogenology. 2013;80:855-61.
2. Chanvallon A, Coyral-Castel S, Gatien J, Lamy JM, Ribaud D, Allain C, et al. Comparison
of three devices for the automated detection of estrus in dairy cows. Theriogenology.
2014;82:734-41.
3. Lane EA, Austin EJ, Crowe MA. Oestrous synchronization in cattle – Current options
following the EU regulations restricting use of oestrogenic compounds in food-producing
animals: a review. Anim Reprod Sci. 2008;109:1-16.
4. Johnson, SK. Possibilities with today´s reproductive technologies. Theriogenology.
2005;64:639-56.
5. Baruselli PS, Reis EL, Marques MO, Nasser LF, Bo GA. The use of hormonal treatments
to improve reproductive performance of anestrous beef cattle in tropical climates. Anim
Reprod Sci. 2004;82-83:479-86.
6. Butler SAA, Phillips NJ, Boe-Hansen GB, Bo GA, Burns BM. Ovarian responses in Bos
indicus heifers treated to synchronize ovulation with intravaginal progesterone releasing
devices, estradiol benzoate, prostaglandin F2α and equine chorionic gonadotrophin. Anim
Reprod Sci. 2011;129:118-26.
7. Souza ALB, Kozicki LE, Pereira JFS, Segui MS, Weiss RR, Bertol MAF. Eficiência da
gonadotrofina coriônica equina (eCG) e do desmame temporário (DT) em protocolos para a
inseminação artificial em tempo fixo (IATF) em vacas Nelore, previamente tratadas com
progesterona (P4) e Benzoato de Estradiol (BE). Arch Vet Sci. 2015;20:22-9.
8. Sá Filho OG, Meneghetti M, Peres RFG, Lamb GC, Vasconcelos JLM. Fixed-time
artificial insemination with estradiol and progesterone for Bos indicus cows II: strategies and
factors affecting fertility. Theriogenology. 2009;72:210-8.
9. Sá Filho MF, Ayres H, Ferreira RM, Marques MO, Reis EL, Silva ECP, et al. Equine
chorionic gonadotropin and gonadotropin-releasing hormoneenhance fertility in a
norgestomet-based, timed artificial insemination protocol in suckled Nelore (Bos indicus).
Cows. Theriogenology. 2010;73:651-8.
10. Macmillan KL, Burke CR. Effects of estrus cycle control on reproductive efficiency.
Anim Reprod Sci. 1996;42:307-20.
11. Kozicki LE, Lopes HB, Feroldi TM, Cordeiro CG, Foltran GB, Segui MS, et al.
Deslorelin as inductor of ovulation in bos taurus x bos indicus after previous exposure to
intravaginal progesterone. Acad J Agric Res. 2013;1:36-8.
12. Frares LF, Weiss RR, Kozicki LE, Santangelo RP, Abreu RA, Santos IW, et al. Estrus
synchronization and Fixed Time Artificial Insemination (FTAI) in dairy buffaloes during
seasonal anestrus. Braz Arch Biol Technol. 2013;56:575-80.
13. Padula AM, Macmillan KL. Reproductive responses of early postpartum dairy cattle to
continuous treatment with a GnRH agonist (deslorelin) for 28 days to delay the resumption of
ovulation. Anim Reprod Sci. 2002;70:23-36.
14. Öztürk OA, Cirit Ü, Baran AK. Is Doublesynch protocol a new alternative for timed
artificial insemination in anestrous dairy cows. Theriogenology. 2010;73:568-76.
15. Lowman BG, Scott N, Somerville S. Condition scoring beef cattle. Edingburgh: East of
Scotland College of Agriculture; 1976. (Bulletin 6).
16. Ginther OJ, Wiltbank MC, Fricke PM, Gibbson JR, Kot K. Selection of the dominant
follicle in cattle. Biol Reprod. 1996;55:1187-94.
17. Pursley JR, Mee MO, Wiltbank MC. Synchronization of ovulation in dairy cows using
PGF2alpha and GnRH. Theriogenology. 1995;44:915-23.
18. Gaievski FR, Lamb GC, Weiss RR, Bertol MAF, Segui MS, Abreu ACMR, et al.
Gonadotropin releasing hormone (GnRH) and equine chorionic gonadotropin (ECG) improve
the pregnancy rate on protocol ls for timed-artificial insemination in beef cattle. Vet Zootec.
2015;22:471-80.
19. Sá Filho OG, Vasconcelos JLM. Treatments to optimize the use of artificial insemination
and reproductive efficiency in beef Cattle under tropical environments. Vet Med Int. 2011:1-
10.
20. Wiltbank MC, Pursley JR. The cow as an induced ovulator: timed AI after
synchronization of ovulation. Theriogenology. 2014;81:170-85.
21. Demeterco D, Henry DD, Mercadante VRG, Lamb GC, Gaievsi FR, Weiss B, et al. The
effects of intramuscular or intravenous injections of gonadotropin releasing hormone at fixedtime artificial insemination on pregnancy rates of Bos indicus beef cows. Braz Arch Biol
Technol. 2014;57:361-6.
22. Barreiros TRR, Blaschi W, Santos GMG, Morotti F, Andrade ER, Baruselli PS, Seneda
MM. Dynamics of follicular growth and progesterone concentrations in cyclic and anestrous
suckling Nelore cows (Bos indicus) treated with progesterone, equine chorionic gonadotropin,
or temporary calf removal. Theriogenology. 2014;81:651-6.
23. Ambrose JD, Pires MFA, Moreira F, Diaz T, Binelli M, Thatcher WW. Influence of
deslorelin (GnRH-Agonist) implant on plasma progesterone, first wave dominant follicle and
pregnancy in dairy cattle. Theriogenology. 1998;50:1157-70.
24. Rajamahendran R, Ambrose JD, Schmitt EJP, Thatcher MJ, Thatcher WW. Effects of
buserelin injection and deslorelin (GnRH-Agonist) implants on plasma progesterone, LH,
accessory CL formation, Follicle and corpus luteum dynamics in Holstein cows
Theriogenology. 1998;50:1141-55.
25. Bartolome JA, Santos JEP, Pancarci SM, Melendez P, Arteche ACM, Hernandez O, et al.
Induction of ovulation in nonlactating dairy cows and heifers using different doses of a
deslorelin implant. Theriogenology. 2004;61:407-19.
26. Mossman DH, Hanly GJ. A theory of beef production. N Z Vet J. 1977;25:96-100.
27. Ferreira MCN, Miranda R, Figueiredo MA, Costa OM, Palhano HB. Impacto da condição
corporal sobre a taxa de prenhez de vacas da raça nelore sob regime de pasto em programa de
inseminação artificial em tempo fixo (IATF). Semina Cienc Agrar. 2013;34:1861-8.
synchronization protocols on the estrus behavior and conception in native Korean cattle
(Hanwoo). Theriogenology. 2013;80:855-61.
2. Chanvallon A, Coyral-Castel S, Gatien J, Lamy JM, Ribaud D, Allain C, et al. Comparison
of three devices for the automated detection of estrus in dairy cows. Theriogenology.
2014;82:734-41.
3. Lane EA, Austin EJ, Crowe MA. Oestrous synchronization in cattle – Current options
following the EU regulations restricting use of oestrogenic compounds in food-producing
animals: a review. Anim Reprod Sci. 2008;109:1-16.
4. Johnson, SK. Possibilities with today´s reproductive technologies. Theriogenology.
2005;64:639-56.
5. Baruselli PS, Reis EL, Marques MO, Nasser LF, Bo GA. The use of hormonal treatments
to improve reproductive performance of anestrous beef cattle in tropical climates. Anim
Reprod Sci. 2004;82-83:479-86.
6. Butler SAA, Phillips NJ, Boe-Hansen GB, Bo GA, Burns BM. Ovarian responses in Bos
indicus heifers treated to synchronize ovulation with intravaginal progesterone releasing
devices, estradiol benzoate, prostaglandin F2α and equine chorionic gonadotrophin. Anim
Reprod Sci. 2011;129:118-26.
7. Souza ALB, Kozicki LE, Pereira JFS, Segui MS, Weiss RR, Bertol MAF. Eficiência da
gonadotrofina coriônica equina (eCG) e do desmame temporário (DT) em protocolos para a
inseminação artificial em tempo fixo (IATF) em vacas Nelore, previamente tratadas com
progesterona (P4) e Benzoato de Estradiol (BE). Arch Vet Sci. 2015;20:22-9.
8. Sá Filho OG, Meneghetti M, Peres RFG, Lamb GC, Vasconcelos JLM. Fixed-time
artificial insemination with estradiol and progesterone for Bos indicus cows II: strategies and
factors affecting fertility. Theriogenology. 2009;72:210-8.
9. Sá Filho MF, Ayres H, Ferreira RM, Marques MO, Reis EL, Silva ECP, et al. Equine
chorionic gonadotropin and gonadotropin-releasing hormoneenhance fertility in a
norgestomet-based, timed artificial insemination protocol in suckled Nelore (Bos indicus).
Cows. Theriogenology. 2010;73:651-8.
10. Macmillan KL, Burke CR. Effects of estrus cycle control on reproductive efficiency.
Anim Reprod Sci. 1996;42:307-20.
11. Kozicki LE, Lopes HB, Feroldi TM, Cordeiro CG, Foltran GB, Segui MS, et al.
Deslorelin as inductor of ovulation in bos taurus x bos indicus after previous exposure to
intravaginal progesterone. Acad J Agric Res. 2013;1:36-8.
12. Frares LF, Weiss RR, Kozicki LE, Santangelo RP, Abreu RA, Santos IW, et al. Estrus
synchronization and Fixed Time Artificial Insemination (FTAI) in dairy buffaloes during
seasonal anestrus. Braz Arch Biol Technol. 2013;56:575-80.
13. Padula AM, Macmillan KL. Reproductive responses of early postpartum dairy cattle to
continuous treatment with a GnRH agonist (deslorelin) for 28 days to delay the resumption of
ovulation. Anim Reprod Sci. 2002;70:23-36.
14. Öztürk OA, Cirit Ü, Baran AK. Is Doublesynch protocol a new alternative for timed
artificial insemination in anestrous dairy cows. Theriogenology. 2010;73:568-76.
15. Lowman BG, Scott N, Somerville S. Condition scoring beef cattle. Edingburgh: East of
Scotland College of Agriculture; 1976. (Bulletin 6).
16. Ginther OJ, Wiltbank MC, Fricke PM, Gibbson JR, Kot K. Selection of the dominant
follicle in cattle. Biol Reprod. 1996;55:1187-94.
17. Pursley JR, Mee MO, Wiltbank MC. Synchronization of ovulation in dairy cows using
PGF2alpha and GnRH. Theriogenology. 1995;44:915-23.
18. Gaievski FR, Lamb GC, Weiss RR, Bertol MAF, Segui MS, Abreu ACMR, et al.
Gonadotropin releasing hormone (GnRH) and equine chorionic gonadotropin (ECG) improve
the pregnancy rate on protocol ls for timed-artificial insemination in beef cattle. Vet Zootec.
2015;22:471-80.
19. Sá Filho OG, Vasconcelos JLM. Treatments to optimize the use of artificial insemination
and reproductive efficiency in beef Cattle under tropical environments. Vet Med Int. 2011:1-
10.
20. Wiltbank MC, Pursley JR. The cow as an induced ovulator: timed AI after
synchronization of ovulation. Theriogenology. 2014;81:170-85.
21. Demeterco D, Henry DD, Mercadante VRG, Lamb GC, Gaievsi FR, Weiss B, et al. The
effects of intramuscular or intravenous injections of gonadotropin releasing hormone at fixedtime artificial insemination on pregnancy rates of Bos indicus beef cows. Braz Arch Biol
Technol. 2014;57:361-6.
22. Barreiros TRR, Blaschi W, Santos GMG, Morotti F, Andrade ER, Baruselli PS, Seneda
MM. Dynamics of follicular growth and progesterone concentrations in cyclic and anestrous
suckling Nelore cows (Bos indicus) treated with progesterone, equine chorionic gonadotropin,
or temporary calf removal. Theriogenology. 2014;81:651-6.
23. Ambrose JD, Pires MFA, Moreira F, Diaz T, Binelli M, Thatcher WW. Influence of
deslorelin (GnRH-Agonist) implant on plasma progesterone, first wave dominant follicle and
pregnancy in dairy cattle. Theriogenology. 1998;50:1157-70.
24. Rajamahendran R, Ambrose JD, Schmitt EJP, Thatcher MJ, Thatcher WW. Effects of
buserelin injection and deslorelin (GnRH-Agonist) implants on plasma progesterone, LH,
accessory CL formation, Follicle and corpus luteum dynamics in Holstein cows
Theriogenology. 1998;50:1141-55.
25. Bartolome JA, Santos JEP, Pancarci SM, Melendez P, Arteche ACM, Hernandez O, et al.
Induction of ovulation in nonlactating dairy cows and heifers using different doses of a
deslorelin implant. Theriogenology. 2004;61:407-19.
26. Mossman DH, Hanly GJ. A theory of beef production. N Z Vet J. 1977;25:96-100.
27. Ferreira MCN, Miranda R, Figueiredo MA, Costa OM, Palhano HB. Impacto da condição
corporal sobre a taxa de prenhez de vacas da raça nelore sob regime de pasto em programa de
inseminação artificial em tempo fixo (IATF). Semina Cienc Agrar. 2013;34:1861-8.
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Publicado
2017-06-30
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1.
Sincero Rabelo de Oliveira L, Luiz Bastos de Souza A, Ernandes Kozicki L, Segui M, Breno Pedosa V, Dell’Aqua Junio JA, Romualdo Weiss R, Machinski Rangel de Abreu AC. POTENCIAL DE LA DESLORELINA COMO AGENTE INDUCTOR DE LA OVULACIÓN EN VACAS PRIMÍPARAS Bos taurus indicus EN LA INSEMINACIÓN ARTIFICIAL EN TIEMPO FIJO. RVZ [Internet]. 30 de junio de 2017 [citado 3 de diciembre de 2024];24(2):363-72. Disponible en: https://rvz.emnuvens.com.br/rvz/article/view/317
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