SARS-COV-2 EM CÃES E GATOS – REVISÃO DE LITERATURA
DOI:
https://doi.org/10.35172/rvz.2022.v29.676Palavras-chave:
animais de companhia, COVID-19, epidemiologiaResumo
Ao final de 2019, um novo coronavírus foi identificado na China, em pacientes com pneumonia severa. Desde sua descoberta, o SARS-CoV-2 se disseminou rapidamente por todo o mundo. Esta revisão de literatura foi realizada para definir o papel de cães e gatos na epidemiologia do SARS-CoV-2. O coronavírus pertence à família Coronaviridae, gêneros Betacoronavírus, é o agente causador da COVID-19 humana e apresenta glicoproteínas de pico que permitem a entrada do vírus na célula hospedeira, por meio da ligação da proteína de pico com os receptores da enzima conversora de angiotensina tipo 2. Não há relatos de que animais de companhia sejam fonte de infecção para seres humanos, entretanto, evidências apontam que humanos infectados possam transmitir partículas virais para os animais de forma natural. Animais infectados podem apresentar sinais clínicos leves e autolimitantes. Assim cães e gatos podem adquirir o SARS-CoV-2 de seus tutores e podem transmitir para outros animais, mas não para humanos e que é importante o entendimento da susceptibilidade de cães e gatos devido ao seu contato próximo com seres humanos.
Referências
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382(8): 727-733. doi: 10.1056/nejmoa2001017 DOI: https://doi.org/10.1056/NEJMoa2001017
Bosco-Lauth AM, Harwig AE, Porter SM, Gordy PW, Nehring M, Byas AD et al. Experimental infection of domestic dogs and cats with SARS-CoV-2: pathogenesis, transmission, and response to reexposure in cats. Proc Natl Acad Sci US 2020: 117(42): 26382-26388. doi: 10.1073/pnas.2013102117 DOI: https://doi.org/10.1073/pnas.2013102117
Leroy EM, Gouilh MA, Brugère-Picoux J. The risk of SARS-CoV-2 transmission to pets and other wild and domestic animals strongly mandates a one-health strategy to control the COVID-19 pandemic. One Health 2020; 10: 100133. doi: 10.1016/j.onehlt.2020.100133 DOI: https://doi.org/10.1016/j.onehlt.2020.100133
Decaro N, Balboni A, Bertolotti L, Martino PA, Mazzei M, Mira F et al. SARS-CoV-2 infection in dogs and cats: facts and speculations. Front Vet Sci 22021; 8: 619207. doi: 10.3389/fvets.2021.619207 DOI: https://doi.org/10.3389/fvets.2021.619207
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798): 270-273. doi: 10.1038/s41586-020-2012-7 DOI: https://doi.org/10.1038/s41586-020-2012-7
Kim YI, Kim SG, Kim SM, Kim EH, Park SJ, Yu KM et al. Infection and rapid transmission of SARS-CoV-2 in ferrets. Cell Host Microbe 2020; 27(5): 704-709. doi: 10.1016/j.chom.2020.03.023 DOI: https://doi.org/10.1016/j.chom.2020.03.023
Wong G, Bi YH, Wang QH, Chen XW, Zhang ZG, Yao YG. Zoonotic origins of human coronavirus 2019 (HCoV-19/SARS-CoV-2): why is this work important? Zool Res 2020; 41(3): 213-219. doi: 10.24272/j.issn.2095-8137.2020.031 DOI: https://doi.org/10.24272/j.issn.2095-8137.2020.031
Wu L, Chen Q, Liu K, Wang J, Han P, Zhang Y et al. Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2. Cell Discov 2020; 6: 68. doi: 10.1038%2Fs41421-020-00210-9 DOI: https://doi.org/10.1038/s41421-020-00210-9
Andersen KG, Bambaut A, Lipkin WI, Homes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020; 26(4): 450-455. doi: 10.1038/s41591-020-0820-9 DOI: https://doi.org/10.1038/s41591-020-0820-9
CDC – Centers for Disease Control and Prevention. [2021]. SARS-CoV-2 is transmitted by exposure to infectious respiratory fluids. [citado 20 Mai 2021]. Disponível em https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/sars-cov-2-transmission.html
Boni MF, Lemey P, Jiang X, Lam TTY, Perry BW, Castoe TA et al. Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic. Nat Microbiol 2020; 5(11): 1408-1417. doi: 10.1038/s41564-020-0771-4 DOI: https://doi.org/10.1038/s41564-020-0771-4
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020; 395(10224): 565-574. doi: 10.1016/S0140-6736(20)30251-8 DOI: https://doi.org/10.1016/S0140-6736(20)30251-8
Ahmad T, Khan M, Haroon, Taha HM, Nasir S, Hui J et al. COVID-19: zoonotic aspects. Travel Med Infect Dis 2020; 36: 101607. doi: 10.1016/j.tmaid.2020.101607 DOI: https://doi.org/10.1016/j.tmaid.2020.101607
Zhao J, Cui W, Tian BP. The potential intermediate hosts for SARS-CoV-2. Front Microbiol 2020; 11: 580137. doi: 10.3389/fmicb.2020.580137 DOI: https://doi.org/10.3389/fmicb.2020.580137
Liu Z, Xiao X, Wei X, Li J, Yang J, Tan H et al. Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. J Med Virol 2020; 172(9): 577-582. doi: 10.1002/jmv.25726 DOI: https://doi.org/10.1002/jmv.25726
Lam TTY, Jia N, Zhang YW. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins. Nature 2020; 583 (7815): 282-285. doi: 10.1038/s41586-020-2169-0 DOI: https://doi.org/10.1038/s41586-020-2169-0
Worldometers. [2021]. COVID-19 coronavirus pandemic. [citado 03 Set 2021]. Disponível em https://www.worldometers.info/coronavirus/country/brazil/
Attia YA, El-Saadony MT, Swelum AA, Qattan SY, Al-Qurashi AD, Asiry KA et al. COVID-19: pathogenesis, advances in treatment and vaccine development and environmental impact – an updated review. Environ Sci Pollut Res 2021; 28(18): 22241-22264. doi: 10.1007/s11356-021-13018-1 DOI: https://doi.org/10.1007/s11356-021-13018-1
Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. In: Maier H, Bickerton E, Britton P. Coronaviruses – methods and protocols. 2. ed. New York: Springer-Verlog New York Inc., 2020. 278p.
Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 2019; 17 (3): 181-192. doi: 10.1038/s41579-018-0118-9 DOI: https://doi.org/10.1038/s41579-018-0118-9
Ristow LE, Carvalho OV, Gebara RR. COVID-19 in felines, their role in human health and possible implications for their guardians and health surveillance. Epidemiol Serv Saúde 2020; 29(2): e2020228. doi: 10.5123/s1679-49742020000300005 DOI: https://doi.org/10.5123/S1679-49742020000300005
Uzunian A. Coronavírus SARS-CoV-2 e Covid-19. J Bras Patol Med Lab 2020; 56: e3472020. doi: 10.5935/1676-2444.20200053 DOI: https://doi.org/10.5935/1676-2444.20200053
Scholz JR, Lopes MACQ, Saraiva JFK, Colombo FC. COVID-19, sistema renina-angiotensina, enzima conversora de angiotensina 2 e nicotina: qual a inter-relação? Arq Bras Cardiol 2020; 115(4): 708-711. doi: 10.36660/abc.20200653 DOI: https://doi.org/10.36660/abc.20200653
Shen M, Liu C, Xu R, Ruan Z, Zhao S, Zhang H et al. Predicting the animal susceptibility and therapeutic drugs to SARS-CoV-2 based on spike glycoprotein combined with ACE2. Front Genet 2020; 11: 575012. doi: 10.3389/fgene.2020.575012 DOI: https://doi.org/10.3389/fgene.2020.575012
Wei Y, Aris P, Farookhi H, Xia X. Predicting mammalian species at risk of being infected by SARS-CoV-2 from an ACE2 perspective. Sci Rep 2021; 11: 1702. doi: 10.1038/s41598-020-80573-x DOI: https://doi.org/10.1038/s41598-020-80573-x
Luan J, Lu Y, Jin X, Zhang L. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection. Biochem Biophys Res Commun 2020; 526(1): 165-169. doi: 10.1016/j.bbrc.2020.03.047 DOI: https://doi.org/10.1016/j.bbrc.2020.03.047
Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol 2020; 94(7): e00127-20. [citado 19 Mai 2021]. Disponível em https://jvi.asm.org/content/94/7/e00127-20 DOI: https://doi.org/10.1128/JVI.00127-20
GHKSAR. Detection of low level of COVID-19 virus in pet dog. 2020. [citado 10 Mar 2021]. Disponível em https://www.info.gov.hk/gia/general/202002/28/P2020022800013.htm
GHKSAR. Pet cat tests positive for COVID-19 virus. 2021. [citado 10 Mar 2021]. Disponível em https://www.info.gov.hk/gia/general/202101/04/P2021010400417.htm
GHKSAR. Pet dog further tests positive for antibodies for COVID-19 virus. 2020. [citado 10 Mar 2021]. Disponível em https://www.info.gov.hk/gia/general/202003/26/P2020032600756.htm
CDC – Centers for Disease Control and Prevention. Confirmation of COVID-19 in two pet cats in New York. 2020. [citado 10 Mar 2021]. Disponível em https://www.cdc.gov/media/releases/2020/s0422-covid-19-cats-NYC.html
Newman A, Smith D, Ghai RR, Wallace RM, Torchetti MK, Loiacono C. et al. First reported cases of SARS-CoV-2 infection in companion animals – New York, March-April 2020. Morb Mortal Wkly Rep 2020; 69(23): 710-713. doi: 10.15585/mmwr.mm6923e3 DOI: https://doi.org/10.15585/mmwr.mm6923e3
Zhang Q, Zhang H, Gao J, Huang K, Yang Y, Hui X et al. A serological survey of SARS-CoV-2 in cats in Wuhan. Emerg Microbes Infect 2020; 9(1): 2013-2019. doi: 10.1080/22221751.2020.1817796 DOI: https://doi.org/10.1080/22221751.2020.1817796
Shi J, Wen Z, Zhong G, Yang H, Wang C, Huang B et al. Susceptibility of ferrets, dogs, and other domesticated animals to SARS-coronavirus 2. Science 2020; 368(6494): 1016-1020. doi: 10.1126/science.abb7015 DOI: https://doi.org/10.1126/science.abb7015
Patterson EI, Elia G, Grassi A, Giordano A, Desario C, Medardo M et al. Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy. Nat Commun 2020; 11: 6231. doi: 10.1038/s41467-020-20097-0 DOI: https://doi.org/10.1038/s41467-020-20097-0
Gandra A. Pesquisa mostra taxa maior de infecção de animais pela covid-19. 2021. [citado 27 Mai 2021]. Disponível em https://agenciabrasil.ebc.com.br/saude/noticia/2021-04/pesquisa-mostra-taxa-maior-de-infeccao-de-animais-pela-covid-19
Calvet GA, Pereira SA, Ogrzewalska M, Pauvolid-Corrêa A, Resende PC, Tassianri WS et al. Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil. PLoS ONE 2021; 16(4): e0250853. doi: 10.137/1/journal.pone.025853 DOI: https://doi.org/10.1371/journal.pone.0250853
Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicy reported confirmed cases: estimation and application. Ann Intern Med 2020; 179(9): 577-582. doi: 10.7326/M20-0504 DOI: https://doi.org/10.7326/M20-0504
Noh JY, Yoon JG, Seong H, Choi WS, Sohn JW, Cheong HJ et al. Asymptomatic infection and atypical manifestations of COVID-19: comparison of viral shedding duration. J Infect 2020; 81 (5): 816-846. doi: 10.1016/j.jinf.2020.05.035 DOI: https://doi.org/10.1016/j.jinf.2020.05.035
Ferasin L, Fritz M, Ferasin H, Becquart P, Legros V, Leroy EM. Myocarditis in naturally infected pets with the Brithish variant of COVID-19. 2021. BioRxiv (Preprint). doi: 10.1101/2021.03.18.435945 DOI: https://doi.org/10.1101/2021.03.18.435945
Lopes LR, Cardillo GM, Paiva PB. Molecular Evolution and phylogenetic analysis of SARS-CoV-2 and hosts ACE2 protein suggest Malayan pangolin as intermediary host. Braz J Microbiol 2020; 51(4): 1593-1599. doi: 10.1007/s42770-020-00321-1 DOI: https://doi.org/10.1007/s42770-020-00321-1
Sit THC, Brackman CJ, Ip SM, Tam KWS, Law PYT, To EMW et al. Infection of dogs with SARS-CoV-2. Nature 2020; 586(7831): 776-778. doi: 10.1038/s41586-020-2334-5 DOI: https://doi.org/10.1038/s41586-020-2334-5
Gaudreault NN, Trujillo JD, Carossino M, Meekings IM, Madden DW, Indran SV et al. SARS-CoV-2 infection, disease and transmission in domestic cats. Emerg Microbes Infect 2020; 9(1): 2322-2332. doi: 10.1080/22221751.2020.1833687 DOI: https://doi.org/10.1080/22221751.2020.1833687
Barrs VR, Peiris M, Tam KWS, Lawm PYT, Brackman CJ, To EMW et al. SARS-CoV-2 in quarantined domestic cats from COVID-19 households or close contacts, Hong Kong, China. Emerg Infect Dis 2020; 26(2): 3071-3074. doi: 10.3201/eid2612.202786 DOI: https://doi.org/10.3201/eid2612.202786
Bao L, Song Z, Xue J, Gao H, Liu J, Wang J et al. Susceptibility and attenuated transmissibility of SARS-CoV-2 in domestic cats. J Infect Dis 2021; 223(8): 1313-1321. doi: 10.1093/infdis/jiab104 DOI: https://doi.org/10.1093/infdis/jiab104
PROMED. Coronavirus disease 2019 update (56): China (Hong Kong) animal, dog, final serology positive. 2020. [citado 23 Mar 2021]. Disponível em https://promedmail.org/promed-post/?id=20200326.7146438
PROMED. Coronavirus disease 2019 update (45): China (Hong Kong) animal, dog second case PCR positive. 2020. [citado 23 Mar 2021]. Disponível em https://promedmail.org/promed-post/?id=20200319.7112693
Zhai X, Sun J, Yan Z, Zhang J, Zhao J, Zhao Z et al. Comparison of severe acute respiratory syndrome coronavirus 2 spike protein binding to ACE2 receptors from human, pets, farm animals, and putative intermediate hosts. J Virol 2020; 94(15): e00831-20. [citado 20 Mai 2021]. Disponível em https://jvi.asm.org/content/jvi/94/15/e00831-20.full.pdf DOI: https://doi.org/10.1128/JVI.00831-20
Grysseels S, De Bruyn L, Gyselings R, Calvignac-Spencer S, Leendertz FH, Leirs H. Risk of human-to-wildlife transmission of SARS-CoV-2. Mamm Rev 2021; 51(2): 272-292. doi: 10.1111/mam.12225 DOI: https://doi.org/10.1111/mam.12225
Percedo-Abreu MI, COVID-19, your pet and other animals: are you at risk? MEDICC Rev 2020; 22(4): 81-82. doi: 10.37757/MR2020.V22.N4.8 DOI: https://doi.org/10.37757/MR2020.V22.N4.8
CDC – Centers for Disease Control and Prevention. COVID-19 – Recommendations for pet stores, pet distributors, and pet breeding facilities. 2020. [citado 20 Jan 2021]. Disponível em https://stacks.cdc.gov/view/cdc/89974/cdc_89974_DS1.pdf?
Hart R. Russia produces world’s first batch of animal covid vaccine. 2021. [citado 27 Mai 2021]. Disponível em https://www.forbes.com/sites/roberthart/2021/04/30/russia-produces-worlds-first-batch-of-animal-covid-vaccine/?sh=2effbaeb11f6
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.