USO DE INIBIDORES DE COX-2 NO TRATAMENTO DO CARCINOMA DE CÉLULAS DE TRANSIÇÃO DE BEXIGA EM CÃES – REVISÃO

Autores

  • Paulo César Jark
  • Luiz Henrique de Araújo Machado
  • Maria Lúcia Gomes Lourenço Lourenço
  • Michiko Sakate

Palavras-chave:

bexiga, carcinoma de células de transição, COX-2, oncologia

Resumo

Nas últimas décadas diversos estudos têm sido realizados correlacionando o desenvolvimento e progressão de alguns tipos de neoplasias com a presença da cicloxigenase-2 (COX-2) e consequentemente superprodução de prostaglandinas nas células tumorais. Os mecanismos envolvidos neste processo são a inibição da  apoptose, a indução de angiogênese, o estímulo à proliferação celular, o aumento na capacidade de invasão tumoral (favorecendo os mecanismos de metástase) e a supressão do sistema imune. A partir destas observações, o uso de inibidores de COX-2 foi sugerido em alguns tipos de neoplasias especialmente no carcinoma de células de transição de bexiga.  Neste contexto, o presente trabalho consiste da revisão de literatura sobre o uso de inibidores de COX-2 no tratamento do carcinoma de células de transição de bexiga em cães.

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Publicado

2022-08-10

Como Citar

1.
Jark PC, Machado LH de A, Lourenço MLGL, Sakate M. USO DE INIBIDORES DE COX-2 NO TRATAMENTO DO CARCINOMA DE CÉLULAS DE TRANSIÇÃO DE BEXIGA EM CÃES – REVISÃO. RVZ [Internet]. 10º de agosto de 2022 [citado 14º de outubro de 2024];18(4):523-30. Disponível em: https://rvz.emnuvens.com.br/rvz/article/view/1044

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