THE USE OF COX-2 INHIBITOR IN THE TREATMENT OF TRANSITIONAL CELL CARCINOMA OF URINARY BLADDER IN DOGS – REVIEW
Keywords:
bladder, transitional cell carcinoma, COX-2, oncologyAbstract
Recently several studies have been performed correlating the development and progression of some types of cancer with cyclooxygenase 2 (COX-2) use and therefore the production of prostaglandins in human and animals tumor cells. The mechanisms involved in this process are the inhibition of apoptosis, induction of angiogenesis, stimulating cell proliferation, increased tumor invasiveness (favoring metastasis mechanisms) and the suppression of the immune system. These observations suggested the benefits with the use of COX-2 inhibitor in some types of cancer, especially of transitional cell bladder carcinoma. In this context, this paper aims to briefly review the literature of COX-2 inhibitor use in the treatment of transitional cell carcinoma of the urinary bladder in dogs.
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