PARASITIC RESISTANCE OF GASTROINTESTINAL NEMATODES IN GOATS CREATED IN A SEMIARID REGION OF PERNAMBUCO, NORTHEASTERN BRAZIL

Authors

DOI:

https://doi.org/10.35172/rvz.2021.v28.523

Keywords:

Goat, Anthelmintic, Helminthiasis, Pernambuco.

Abstract

This study aimed to investigate the situation of parasite resistance in goat farms located in Petrolina municipality, São Francisco Valley region, Northeastern Brazil. Four-hundred and twenty goats of both sexes, older than seven months, and with the highest parasite load were selected from each of the 10 farms and were divided into six homogeneous groups of seven animals. Each group was treated with an anthelmintic drug: Group I–Ivermectin 0.08%; Group II–Albendazole 10%; Group III–Levamisole 5%; Group IV–Moxidectin 1%; Group V–Closantel 10%; and Group VI–Control (no treatment). The samples were collected on days D0 (before treatment), D7, D14 and D21 post-treatment. The Fecal Egg Count Reduction Test (FECRT) was applied to evaluate anthelmintic resistance. The groups treated with Moxidectin showed inefficacy in D7 and low efficacy in D14, with an average reduction of 79.8% and 88.69%, but high efficacy in D21 (93.43%). Closantel showed low efficacy with average of 84.72% only in D14. Levamisole, Albendazole and Ivermectin showed drug inefficacy, with averages lower than 80%. All the tested drugs except moxidectin (D21) showed less than 90% antiparasitic efficacy in the goat herds, indicating the presence of parasites with multidrug resistance.

References

1. Igarashi M, Carvalho DMG, Bucci FC, Miranda Y, Rodrigues ZM, Almeida MCF, et al. Efeito do neem (Azadirachta Indica) no controle de nematódeos gastrintestinais em ovinos suplementados a pasto no período seco. Semin Ciênc Agrar. 2013;34(1):301-10. DOI: 10.5433/1679-0359.2013v34n1p301.

2. Vieira LS. Métodos alternativos de controle de nematóides gastrintestinais em caprinos e ovinos. Rev Tecnol Ciên Agropec. 2008;2:49-56. Available from: < http://revistatca.pb.gov.br/edicoes/volume-02-2008/volume-2-numero-2-junho-2008/tca09_metodos.pdf>.

3. Rinaldi LE, Cringoli G. Parasitological and pathophysiological methods for selective application of anthelmintic treatments in goats. Small Ruminant Res. 2012;10(1):18-22. DOI: 10.1016/j.smallrumres.2011.10.014.

4. Melo ACFL, Reis IF, Belaviqua CML, Vieira LS, Ecchevarria FAM, Melo LM, et al. Nematódeos resistentes a anti-helmínticos em rebanhos de ovinos e caprinos do estado do Ceará, Brasil. Cienc Rural. 2003;33(2):339-344. DOI: 10.1590/S0103-84782003000200024.

5. Sangster NC. Managing parasiticide resistance. Vet Parasitol. 2001;98(1-3):89-109. DOI: 10.1016/S0304-4017(01)00425-3.

6. Borges CCL. Atividade in vitro de anti-helmínticos sobre larvas infectantes de nematódeos gastrintestinais de caprinos, utilizando-se a técnica de coprocultura quantitativa (Ueno, 1995). Parasitología Latinoamericana. 2003; 58:142-7. DOI: 10.4067/S0717-77122003000300010.

7. Conder GA, Campbell WC. Chemotherapy of nematode infections of veterinary importance with special reference to drug resistence. Adv Parasitol. 1995;35:1-84. DOI: 0.1016/S0065-308X(08)60069-X.

8. Nari, A H. Towards sustainable parasite control practices in livestock production with emphasis in Latin America. Vet Parasitol. 2011;180(1-2):2-11. DOI: 10.1016/j.vetpar.2011.05.026.

9. IBGE. Instituto Brasileiro de Geografia e Estatística. Produção da Pecuária Municipal (Economia, Agropecuária, Produção Pecuária). Dados 2004 a 2011. 2012 [cited 2016 Dec 09]. Available from: <http://www.ibge.gov.br/home/estatistica/ pesquisas/pesquisa_resultados.php?id_pesquisa=21>. https://biblioteca.ibge.gov.br/index.php/biblioteca-catalogo?id=784&view=detalhes

10. Holanda Júnior V, Martins EC. Análise da produção e do mercado de produtos caprinos e ovinos: o caso do território do sertão do Pajeú em Pernambuco. Infoteca EMBRAPA. 2008. [cited 2016 Dec 09]. Available from: < http://www.infoteca.cnptia.embrapa.br/>.

11. CNPM. 2014. [cited 2016 Dec 09]. Available from: http://www.urbanizacao.cnpm.embrapa.br/conteudo/uf/pe.html.

12. IBGE. Instituto Brasileiro de Geografia e Estatística. Censo agropecuário, Petrolina, 2017. [cited 2018 Agu 09]. Available from: <https://cidades.ibge.gov.br/brasil/pe/petrolina/pesquisa/24/76693>.

13. Gordon HM, Whitlock HV. A new technique for counting nematode eggs in sheep faeces. J Sci Ind Res. 1939;12(1):50-2. Available from: <https://publications.csiro.au/rpr/download?pid=procite:21259a33-8a8e-4add-9315-f8338091a3e6&dsid=DS1>.

14. Roberts FHS, O’Sullivan JP. Methods of egg counts and larval cultures for strongyles infesting the gastrointestinal tract of cattle. Aust J Agric Res. 1950;1(1):99-102. DOI: 10.1071/AR9500099.

15. Keith RK. The differential of the infective larvae of some common nematode parasites of cattle. Aust J Zool. 1953;1(2):223-230. DOI: 10.1071/ZO9530223.

16. Coles GC. Anthelmintic resistance–looking to the future: a UK perspective. Res Vet Sci. 2005;78(2):99-108. DOI:10.1016/j.rvsc.2004.09.001.

17. Coles GC, Jackson F, Pomroy WE, Prichard RK, Himmelstjerna GVS, Silvestre A, et al. The detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol. 2006;136(3-4):167–185. DOI: 10.1016/j.vetpar.2005.11.019.

18. Zar JH. Biostatistical Analysis. New Jersey: Prentice Hall, 1999.

19. Papadopoulos E, Mavrogianni VS, Ptochos S, Tsakalidis S, Fthenakis C. Evaluation of the efficacy of moxidectin in a herd of goats after long-standing consistent use. Small Ruminant Res. 2005;57(2-3):271-5. DOI: 10.1016/j.smallrumres.2004.08.006.

20. Borges SL, Oliveira AA, Mendonça LR, Lambert SM, Viana JM, Nishi SM, et al. Resistência anti-helmíntica em rebanhos caprinos nos biomas Caatinga e Mata Atlântica. Pesq Vet Bras. 2015;35(7):643-8. DOI: 10.1590/S0100-736X2015000700007.

21. Ahid SMM, Cavalcante MDA, Bezerra ACDS, Soares HSS, Pereira RHMA. Eficácia anti-helmíntica em rebanho caprino no estado de Alagoas, Brasil. Acta Vet Bras. 2007;1(2):56-9. DOI: 10.21708/avb.2007.1.2.281.

22. Lima MM, Farias MPO, Romeiro ET, Ferreira DRA, Alves LC, Faustino MAG. Eficácia da moxidectina, ivermectina e albendazole contra helmintos gastrintestinais em propriedades de criação caprina e ovina no Estado de Pernambuco. Ci Anim Bras. 2010ª;11(1):94-100. DOI: 10.5216/cab.v11i1.1103.

23. Traversa D, Paoletti B, Miller J. First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy. Parasitol Res. 2007;101(6):1713-16. DOI: 10.1007/s00436-008-0934-3.

24. Melo ACFL, Belaviqua CML, Selaive AV, Girão MD. Resistência a anti-helmínticos em nematóides gastrintestinais de ovinos e caprinos, no município de Pentecoste, Estado do Ceará. Cien Animal. 1998;8(1):7-11. Available from: < http://www.uece.br/cienciaanimal/dmdocuments/Artigo1.1998.1.pdf>.

25. Sczesny-moraes EA, Biachin I, Silva KF, Catoo JB, Honer MR, Paiva F. Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul. Pesq Vet Bras. 2010;30(3):229-236. DOI: 10.1590/S0100-736X2010000300007.

26. Lima WC, Athayde ACR, Medeiros GR, Lima DASD, Borburema JB, Santos EM, et al. Nematóides resistentes a alguns anti-helmínticos em rebanhos caprinos no Cariri Paraibano. Pesq Vet Bras. 2010b;30(12):1003-9. DOI: 10.1590/S0100-736X2010001200001.

27. Pereira RHMA, Ahid SMM, Bezerra ACDS, Soares HS, Fonseca ZAAS. Diagnóstico da resistência dos nematóides gastrintestinais a anti-helmínticos em rebanhos caprino e ovino do RN. Acta Vet Bras. 2008;2(1):16-9. DOI: 10.21708/avb.2008.2.1.573.

28. Mattos MJT, Oliveira CMB, Gouvea AS, Andrade CB. Sensibilidade dos nematódeos gastrintestinais de caprinos ao ivermectin na região da Grande Porto Alegre, RS. Acta Scient Vet. 2003;31(3):155-160. DOI: 10.22456/1679-9216.17159.

29. Hennessy DR, Sangster NC, Collins JWSGH. Comparative pharmacokinetic behaviour of albendazole in sheep and goats. Int J Parasitol. 1993;23(3):321-5. DOI: 10.1016/0020-7519(93)90006-K.

30. Rodrigues AB, Athayde ACR, Rodrigues OG, Silva WW, Faria EB. Sensibilidade dos nematóides gastrintestinais de caprinos e ovinos a anti-helmínticos na mesorregião do sertão paraibano. Pesq Vet Bras. 2007;27(4):162-66. DOI: 10.1590/S0100-736X2007000400006.

31. Gooslby MK, Browning MLL, Browning Jr R. Evaluation of parasite resistance to commonly used commercial anthelmintics in meat goats on humid subtropical pasture. Small Ruminant Res. 2017;146:37-40. DOI: 10.1016/j.smallrumres.2016.11.022.

32. Duarte ER. Silva RB, Vasconcelos VO, Nogueira FA, Oliveira NJF. Diagnóstico do controle e perfil de sensibilidade de nematódeos de ovinos ao albendazol e ao levamisol no norte de Minas Gerais. Pesq Vet Bras. 2012;32(2):147-152. DOI: 10.1590/S0100-736X2012000200010.

33. Costa PT, Vaz RZ, Costa RT, Fernandes TA, Farias PP. Eficácia do albendazole, cloridrato de levamisol, moxidectina e nitroxinil no controle parasitário de cordeiras. Revista Científica Rural. 2018;20(1):62-71. Available from: < http://ediurcamp.urcamp.edu.br/index.php/RCR/article/view/168>.

34. Howell SB, Burke JM, Miller JE, Terril TH, Valencia E, Willians MJ, et al. Prevalence of anthelmintic resistance on sheep and goat farms in the southeastern United States. J Am Vet Med Assoc. 2008;233(12):1913-19. DOI: 10.2460/javma.233.12.1913.

35. Ranjan S, Wang GT, Hirschlein C, Simkins KL. Selection for resistance to macrocyclic lactones by Haemonchus contortus in sheep. Vet Parasitol. 2002;103(1-2):109-17. DOI: 10.1016/S0304-4017(01)00551-9.

36. Cezar AS, Toscan G, Camillo G, Sangioni LA, Ribas HO, Vogel FSF. Multiple resistance of gastrointestinal nematodes to nine different drugs in a sheep flock in southern Brazil. Vet Parasitol. 2010;173(1-2):157-160. DOI: 10.1016/j.vetpar.2010.06.013

37. Vilela VLR, Feitosa TF, Linhares EF, Athayde ACR, Molento MB, Azevedo SS. FAMACHA(©) method as an auxiliary strategy in the control of gastrointestinal helminthiasis of dairy goats under semiarid conditions of Northeastern Brazil. Vet Parasitol. 2012;190:281-84. DOI: 10.1016/j.vetpar.2012.05.024.

38. Charles TP, Pompeu J, Miranda DB. Efficacy of three broad-spectrum anthelmintics against gastrointestinal nematode infections of goats. Vet Parasitol. 1989;34:71-75. DOI:10.1016/0304-4017(89)90166-0.

39. Coelho WAC, Ahid SMM, Vieira LS, Fonseca ZAAS, Silva IP. Resistência anti-helmíntica em caprinos no município de Mossoró. Ci Anim Bras. 2010;11(3):589-99. DOI: 10.5216/cab.v11i3.5389.

40. Saeed M, Iqbal Z, Jabbar A, Masood S, Babar W, Saddiqi HÁ, Yassen M, Sarwar M, Arshad M. Multiple anthelmintic resistance and the possible contributory factors in Beetal goats in an irrigated area (Pakistan). Res Vet Sci. 2010;88(2):267-72. DOI: 10.1016/j.rvsc.2009.08.004.

41. Melo ACFL, Rondom FCM, Reis IF, Belaviqua CML. Desenvolvimento da resistência ao oxfendazol em propriedades rurais de ovinos na região do Baixo e Médio Jaguaribe, Ceará, Brasil. Rev Bras Parasitol Vet. 2004;13(4):137-14. Available from: <https://www.researchgate.net/publication/215566184_Desenvolvimento_da_resistencia_ao_oxfendazol_em_propriedades_rurais_de_ovinos_na_regiao_do_baixo_e_medio_Jaguaribe_Ceara_Brasil>.

Published

2021-03-29

How to Cite

1.
de Castro EMS, Souza EAR, Dantas ACS, da Silva IWG, Medeiros de Araújo M, Santos de Azevedo S, Sangioni LA, Horta MC. PARASITIC RESISTANCE OF GASTROINTESTINAL NEMATODES IN GOATS CREATED IN A SEMIARID REGION OF PERNAMBUCO, NORTHEASTERN BRAZIL. RVZ [Internet]. 2021 Mar. 29 [cited 2024 Nov. 23];28:1-12. Available from: https://rvz.emnuvens.com.br/rvz/article/view/523

Issue

Section

Original Articles

Most read articles by the same author(s)