CARDIORESPIRATORY EFFECTS OF DEXMEDETOMIDINE ALONE AND ASSOCIATED TO MORPHINE AS PREMEDICANTS IN HEALTHY BITCHES UNDERGOING OVARIOHISTERECTOMY

Authors

  • Aline Bossa Perotto Discentes do Programa de Pós-Graduação em Residência Veterinária, Universidade Federal de Mato Grosso (UFMT), Campus Cuiabá, Mato Grosso, Brasil.
  • Fernanda Silva Pereira Discentes do Programa de Pós-Graduação em Residência Veterinária, Universidade Federal de Mato Grosso (UFMT), Campus Cuiabá, Mato Grosso, Brasil.
  • Fábio Dumit Pizzinatto Discentes do Programa de Pós-Graduação em Ciências Veterinárias, UFMT, Campus Cuiabá, Mato Grosso, Brasil. https://orcid.org/0000-0002-8234-8590
  • Dábila Araújo Sônego Discentes do Programa de Pós-Graduação em Ciências Veterinárias, UFMT, Campus Cuiabá, Mato Grosso, Brasil. https://orcid.org/0000-0003-4207-8853
  • Andresa de Cássia Martini Professora Doutora, Centro Universitário de Mineiros (UNIFIMES), Campus Mineiros – Mineiros/GO. https://orcid.org/0000-0002-2553-3685
  • Lianna Ghisi Gomes Docentes da Faculdade de Medicina Veterinária (FAVET), UFMT, Campus Cuiabá, Mato Grosso, Brasil. https://orcid.org/0000-0003-0909-2426
  • Alexandre Pinto Ribeiro Docentes da Faculdade de Medicina Veterinária (FAVET), UFMT, Campus Cuiabá, Mato Grosso, Brasil. https://orcid.org/0000-0002-8922-2886
  • Luciana Dambrósio Guimarães Docentes da Faculdade de Medicina Veterinária (FAVET), UFMT, Campus Cuiabá, Mato Grosso, Brasil. https://orcid.org/0000-0001-6447-2718

DOI:

https://doi.org/10.35172/rvz.2022.v29.632

Keywords:

dogs, α-2-agonist, opioids, analgesia

Abstract

This study aimed to evaluate the cardiorespiratory effects of dexmedetomidine alone and associated with morphine. Twenty healthy dogs were selected from physical and laboratory exams. The animals were randomly distributed into two groups: 10 µg/Kg dexmedetomidine (DG) and 10 µg/Kg dexmedetomidine group associated with 0.3 mg/Kg morphine (GDM), administered intramuscularly (IM). The patients were induced with propofol (to effect) and maintained with isoflurane diluted in 100% oxygen and administered through a calibrated vaporizer. Physiological parameters were measured: heart rate (HR), respiratory rate (f), body temperature (T°C), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP), oxygen saturation of hemoglobin (SpO2), end-tidal carbon dioxide partial pressure (ETCO2) and end-tidal isoflurane concentration (ETISO). Arterial blood gas analysis was used to analyze hydrogen potential (pH), bicarbonate (HCO3-) and partial pressure of carbon dioxide (PaCO2). The surgical procedure lasted up to 45 minutes. The parameters showed a statistical difference between the times and groups evaluated, according to the Tukey and Bonferroni tests (p<0.05). Bradycardia was observed 30 minutes after the application of pre-anesthesic medication and acidemia in the trans-anesthetic period. Despite this, both dexmedetomidine alone and associated, provided good hemodynamic and respiratory stability, despite the bradycardia and acidemia observed.

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Published

2022-06-28

How to Cite

1.
Bossa Perotto A, Silva Pereira F, Dumit Pizzinatto F, Araújo Sônego D, de Cássia Martini A, Gomes LG, Pinto Ribeiro A, Dambrósio Guimarães L. CARDIORESPIRATORY EFFECTS OF DEXMEDETOMIDINE ALONE AND ASSOCIATED TO MORPHINE AS PREMEDICANTS IN HEALTHY BITCHES UNDERGOING OVARIOHISTERECTOMY. RVZ [Internet]. 2022 Jun. 28 [cited 2024 Nov. 23];29:1-10. Available from: https://rvz.emnuvens.com.br/rvz/article/view/632

Issue

Vol. 29 (2022)

Section

Original Articles

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