OCCURRENCE OF NATURAL INFECTION FOR Leishmania spp. IN THE DOMICILED AND HUMAN CANINE POPULATION OF TRÊS LAGOAS-MS AND SPATIAL ANALYSIS

Authors

  • Maria Angelina da Silva Zuque Programa de Pós-Graduação em Doenças Tropicais – Faculdade de Medicina de Botucatu – FMB – Universidade Estadual Paulista – UNESP.
  • Suzane Manzini Agência Paulista de Tecnologia dos Agronegócios https://orcid.org/0000-0001-8052-5736
  • Thainá Valente Bertozzo Programa de Pós-Graduação em Doenças Tropicais – Faculdade de Medicina de Botucatu – FMB – Universidade Estadual Paulista – UNESP. https://orcid.org/0000-0002-7971-2021
  • Maria Fernanda Alves Martin Programa de Pós-Graduação em Doenças Tropicais – Faculdade de Medicina de Botucatu – FMB – Universidade Estadual Paulista – UNESP. https://orcid.org/0000-0001-9558-646X
  • Mirian dos Santos Paixão Programa de Pós-Graduação em Doenças Tropicais – Faculdade de Medicina de Botucatu – FMB – Universidade Estadual Paulista – UNESP.
  • Wesley José dos Santos Programa de Pós-Graduação em Doenças Tropicais – Faculdade de Medicina de Botucatu – FMB – Universidade Estadual Paulista – UNESP.
  • Lívia Maisa Guiraldi Programa de Pós-Graduação em Doenças Tropicais – Faculdade de Medicina de Botucatu – FMB – Universidade Estadual Paulista – UNESP.
  • Gabriela Pacheco Sanchez Programa de Pós-Graduação em Medicina Veterinária e Zootecnia – Faculdade de Medicina Veterinária e Zootecnia – FMVZ- Universidade Estadual Paulista – UNESP – Botucatu. https://orcid.org/0000-0002-0394-0589
  • Cilmery Suemi Kurokawa Programa de Pós-Graduação em Doenças Tropicais – Faculdade de Medicina de Botucatu – FMB – Universidade Estadual Paulista – UNESP. https://orcid.org/0000-0003-1380-7527
  • Isabella Neves Aires Faculdade de Ciências, Universidade Estadual Paulista – UNESP – Bauru. https://orcid.org/0000-0001-5285-3150
  • Nássarah Jabur Lot Rodrigues Programa de Pós-Graduação em Doenças Tropicais – Faculdade de Medicina de Botucatu – FMB – Universidade Estadual Paulista – UNESP. https://orcid.org/0000-0003-4970-2903
  • Simone Baldini Lucheis Agência Paulista de Tecnologia dos Agronegócios – APTA/SAA/Bauru https://orcid.org/0000-0002-4842-5281

DOI:

https://doi.org/10.35172/rvz.2022.v29.655

Keywords:

Visceral Leishmaniasis, natural infection, canines, diagnosis.

Abstract

Visceral Leishmaniasis (VL), a neglected disease of chronic and systemic character, caused by the parasite Leishmania spp. represents a public health problem, especially in countries with  vulnerable population, such as Brazil. Due to urbanization, dogs constitute an important reservoir in the disease’s urban cycle, preceding human cases, and contributing to the maintenance of Canine Visceral Leishmaniasis (CVL). However, few serological surveys added to the spatial analysis involving human and animal populations have been described in Três Lagoas. Therefore, the aim of this study was to identify and describe the occurrence of natural infection by Leishmania spp. in the human and domiciled canine population of Três Lagoas - MS, Brazil, using the serological techniques of Dual Path Platform (DPP), Enzyme Linked Immunosorbent Assay (ELISA) and Indirect Immunofluorescence Reaction (RIFI), as well as molecular techniques for Leishmania spp. and spatial analysis. For this study, 566 blood samples were collected from dogs. In addition, epidemiological information was collected from the municipal health system, and subsequently, spatial analysis was performed. As a result, 267 samples were reactive to the DPP test, 267 reactive to ELISA and 97 reactive to RIFI, with 95% of agreement between the DPP and ELISA methods. Sixteen samples submitted to PCR were positive for Leishmania spp. The use of georeferencing for canine CVL in Três Lagoas provided subsidies to identify areas that needed priority intervention for the control of Leishmaniasis. The presence of sandflies, associated with the geographic location, as well as the environmental conditions in the studied region, favored their dissemination, as well as the transmission of the disease to dogs and humans.

References

BI K, CHEN Y, ZHAO S, KUANG Y, JOHN WU CH. Current Visceral LeishmaniasisResearch: A Research Review to Inspire Future Study. Biomed Res Int. 2018 Jul 10;2018:9872095. doi: 10.1155/2018/9872095. PMID: 30105272; PMCID: PMC6076917 DOI: https://doi.org/10.1155/2018/9872095

MINISTÉRIO DA SAÚDE. Secretaria de Vigilância em Saúde. Coordenação-Geral de Desenvolvimento da Epidemiologia em Serviços. Guia de Vigilância em Saúde: volume único – 3ª. ed. 503-22 – Brasília: Ministério da Saúde. 2019.

REIMÃO JQ, COSER EM, LEE MR, COELHO AC. Laboratory Diagnosis of Cutaneous and Visceral Leishmaniasis: Currentand Future Methods. Microorganisms. 2020 Oct 22;8(11):1632. doi: 10.3390/microorganisms8111632. PMID: 33105784; PMCID: PMC7690623. DOI: https://doi.org/10.3390/microorganisms8111632

WORLD HEALTH ORGANIZATION (WHO). Leishmaniasis. 2021 Disponível em <https://www.who.int/news-room/fact-sheets/detail/leishmaniasis>. Acesso 01 mai 2021.

LACERDA AFA, OLIVERIA DS, SALOMÃO JVF, OLIVEIRA LGR, MONTE-ALEGRE A, SANTOS JYGD, SOUZA CC, MAGALHÃES-JUNIOR JT, ARAÚJO-SANTOS ET. Clinical, epidemiologicalandtransmissioncycleaspectsofleishmaniasisurbanization in Barreiras, Bahia, Brazil. SpatSpatiotemporalEpidemiol. 2021 Feb;36:100395. doi: 10.1016/j.sste.2020.100395. Epub 2020 Dec 11. PMID: 33509434. DOI: https://doi.org/10.1016/j.sste.2020.100395

CARVALHO AG, LUZ JGG, RODRIGUES LD, DIAS JVL, FONTES CJF. High seroprevalenceandperipheralspatialdistributionof visceral leishmaniasisamongdomestic dogs in anemergingurbanfocus in Central Brazil: a cross-sectionalstudy. PathogGlob Health. 2018 Feb;112(1):29-36. doi: 10.1080/20477724.2018.1438229. PMID: 29460695; PMCID: PMC6056830. DOI: https://doi.org/10.1080/20477724.2018.1438229

ILIOPOULOU P, TSATSARIS A, KATSIOS I, PANAGIOTOPOULOU A, ROMALIADES S, PAPADOPOULOS B, et al. Risk mapping of visceral leishmaniasis: A spatialregression model for Atticaregion, Greece. Trop Med InfectDis. 2018;3(3). DOI: https://doi.org/10.3390/tropicalmed3030083

LOPES JV, MICHALSKY EM, MICHALSKY NCL et al. Canine visceral leishmaniasis in area with recent Leishmania transmission: prevalence, diagnosis, and molecular identification of the infecting species. Journal of the Brazilian Society of Tropical Medicine. Vol.:53:(e20200141): 2020. doi: https://doi.org/10.1590/0037-8682-0141-2020 DOI: https://doi.org/10.1590/0037-8682-0141-2020

IBGE. IBGE 2015 [Internet]. Available from: https://cidades.ibge.gov.br/brasil/ms/tres-lagoas/panorama

MINISTÉRIO DA SAÚDE. Manual de Vigilância e Controle da Leishmaniose Visceral. 1ª edição, 5ª reimpressão. Brasília, 2014. https://bvsms.saude.gov.br/bvs/publicacoes/manual_vigilancia_controle_leishmaniose_visceral_1edicao.pdf

BIO-MANGUINHOS. EIE - Leishmaniose Visceral Canina. Ensaio Imunoenzimático para diagnóstico da Leishmaniose Visceral Canina. Rio de Janeiro; 2011.

ELOY LJ, LUCHEIS SB. Hemoculture and Polymerase Chain Reaction Using Primers TCZ1/TCZ2 for the Diagnosis of Canine and Feline Trypanosomiasis. ISRN Vet Sci. 2012;2012:419378. DOI: https://doi.org/10.5402/2012/419378

IKONOMOPOULOS J, KOKOTAS S, GAZOULI M, ZAVRAS A, STOITSIOU M, GORGOULIS VG. Molecular diagnosis of leishmaniosis in dogs. Comparative application of traditional diagnostic methods and the proposed assay on clinical samples. Vet Parasitol. 2003 Apr;113(2):99–113. DOI: https://doi.org/10.1016/S0304-4017(03)00061-X

BRASIL. Abordagens espaciais em saúde pública. Ministério da Saúde,Secretaria Vigilância em Saúde, Fundação Oswaldo Cruz. Brasília: Ministério daSaúde, 2006.136p (Série B. Textos Básicos de Saúde) (Série Capacitação eAtualização em Geoprocessamento em Saúde;1).

FIGUEIREDO FB, VASCONCELOS TCB DE, MADEIRA M DE F, MENEZES RC, MAIA-ELKHOURY ANS, MARCELINO AP, et al. Validation of the Dual-path Platform chromatographic immunoassay (DPP® CVL rapid test) for the serodiagnosis of canine visceral leishmaniasis. Mem Inst Oswaldo Cruz. 2019. Disponível em http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100303&lng=en&tlng=en DOI: https://doi.org/10.1590/0074-02760180260

SRIVIDYA G, KULSHRESTHA A, SINGH R, SALOTRA P. Diagnosis of visceral leishmaniasis: developments over the last decade. Parasitol Res. 2012; 110:1065- 78. DOI: https://doi.org/10.1007/s00436-011-2680-1

OLIVEIRA ALL DE, PANIAGO AMM, DORVAL MEC, OSHIRO ET, LEAL CR, SANCHES M, et al. Foco emergente de leishmaniose visceral em Mato Grosso do Sul. Rev Soc Bras Med Trop. 39(5):446–50. 2006. Disponível em http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000500005&lng=pt&tlng=pt. DOI: https://doi.org/10.1590/S0037-86822006000500005

BRITO VN, DIAS AFLR E SOUSA VRF. Epidemiological aspects of Leishmaniasis in the Pantanal region of Mato Grosso. Braz. J. Vet. Parasitol., Jaboticabal, v. 28, n. 4, p. 744-749. 2019. Doi: https://doi.org/10.1590/S1984-29612019061 DOI: https://doi.org/10.1590/s1984-29612019061

MINISTÉRIO DA SAÚDE. Secretaria de Vigilância em Saúde D de VE. Guia de vigilância em saúde. Brasília. 2017.

BOTELHO ACA, NATAL D. First epidemiological description of visceral leishmaniasis in Campo Grande, State of Mato Grosso do Sul. Rev Soc Bras Med Trop. 42(5):503–8. 2009. DOI: https://doi.org/10.1590/S0037-86822009000500006

MARCONDES M, ROSSI CN. Leishmaniose visceral no Brasil. Brazilian J Vet Res Anim Sci. 29;50(5):341. 2014. Available from: http://www.revistas.usp.br/bjvras/article/view/79913 DOI: https://doi.org/10.11606/issn.2318-3659.v50i5p341-352

OLIVEIRA SS, HIRAMOTO RM, RANGEL O, HENRIQUES LF, VIVIANI JÚNIOR A, TANIGUCHI HH, BARBOSA JER, CASANOVA C, SAMPAIO SMP, SPÍNOLA R, REHDER S, LINDOSO JAL, TOLEZANO JE. Epidemiological classification of the municipalities of the State of São Paulo according to the Visceral Leishmaniasis Control and Surveillance Program, 2018. BEPA, Bol. epidemiol. paul. (Impr.); 16(192): 29-46, 2019.

PRESTES-CARNEIRO LE, DANIEL LAF, ALMEIDA LC, D’ANDREA LZ, VIEIRA AG, ANJOLETE IR, et al. Spatiotemporal analysis and environmental risk factors of visceral leishmaniasis in an urban setting in Sao Paulo State, Brazil. Parasit Vectors. 2019 May;12(1):251. DOI: https://doi.org/10.1186/s13071-019-3496-6

CARVALHO MR, DIAS AFLR, ALMEIDA ABPF, ALVES MR, PAES AS, SOUSA VRF. Canine visceral leishmaniasis: perception, prevalence, and spatial distribution in municipality of Nossa Senhora do Livramento, Mato Grosso, Brazil. Braz J Vet Parsitol 2020; 29(2): e021019. 2020. Doi: https://doi.org/10.1590/S1984-29612020017 DOI: https://doi.org/10.1590/s1984-29612020017

OLIVEIRA AM, LÓPEZ RVM, DIBO MR, RODAS LAC, GUIRADO MM, CHIARAVALLOTI-NETO F. Dispersion of Lutzomyia longipalpis and expansion of visceral leishmaniasis in São Paulo State, Brazil: identification of associated factors through survival analysis. Parasit Vectors. 11(1):503. 2018. DOI: https://doi.org/10.1186/s13071-018-3084-1

PALATNIK-DE-SOUSA CB, BATISTA-DE-MELO LM, BORJA-CABRERA GP, PALATNIK M, LAVOR CC. Improving methods for epidemiological control of canine visceral leishmaniasis based on a mathematical model. Impact on the incidence of the canine and human disease. An Acad Bras Cienc.76(3):583–93. 2004. DOI: https://doi.org/10.1590/S0001-37652004000300012

FERREIRA CGX, OLIVEIRA MD, SUGUIMOTO F, SOUZA RF et al. Retrospective evaluation of American Tegumentary Leishmaniosis confirmed cases in Três Lagoas - MS in the period 2007 to 2019. Brazilian Journal of Development, Curitiba, v.7, n.2, p. 13535-13550. 2021. doi: 10.34117/bjdv7n2-121 [28] PEREIRA JUNIOR AM, SOUZA ABN, CASTRO TS, DA SILVA MS, DE PAULO PFM, FERREIRA GEM, et al. Diversity, natural infection and blood meal sources of phlebotomine sandflies (Diptera, Psychodidae) in the western Brazilian Amazon. Mem Inst Oswaldo Cruz.114:e190170. 2019.

OLIVEIRA GMG, FIGUEIRÓ FILHO EA, ANDRADE GMC, ARAÚJO LA, OLIVEIRA MLG, CUNHA RV. Flebotomíneos (Diptera: Psychodidae: Phlebotominae) no Município de Três Lagoas, área de transmissão intensa de leishmaniose visceral, Estado de Mato Grosso do Sul, Brasil. Rev Pan-Amazônica Saúde. 2010. Disponível em http://scielo.iec.pa.gov.br/scielo.php?script=sci_arttext&pid=S2176-62232010000300012&lng=en&nrm=iso&tlng=em. DOI: https://doi.org/10.5123/S2176-62232010000300012

AZEVEDO TS, LORENZ C, CHIARAVALLOTI-NETO F. Journal of the Brazilian Society of Tropical Medicine. Vol.:52:e20190240: 2019. doi: 10.1590/0037-8682-0240-2019 DOI: https://doi.org/10.1590/0037-8682-0240-2019

CAMPOS R, SANTOS M, TUNON G, CUNHA L et al. Epidemiological aspects and spatial distribution of human and canine visceral leishmaniasis in an endemic area in northeastern Brazil. Geospatial Health, volume 12:503. 2017. DOI: https://doi.org/10.4081/gh.2017.503

FREITAS ROCHA AT, DE ESPINDOLA GM, SOARES MRA, DE RIBAMAR DE SOUSA ROCHA J, COSTA CHN. Visceral leishmaniasis and vulnerability conditions in an endemic urban area of Northeastern Brazil. Trans R Soc Trop Med Hyg.112(7):317–25. 2018. DOI: https://doi.org/10.1093/trstmh/try058

DE ARRUDA RMF, CARDOSO DT, TEIXEIRA-NETO RG, BARBOSA DS et al. Space-time analysis of the incidence of human visceral leishmaniasis (VL)and prevalence of canine VL in a municipality of southeastern Brazil:Identification of priority areas for surveillance and control. Acta Tropica 197, 105052. 2019. doi: https://doi.org/10.1016/j.actatropica.2019.105052 DOI: https://doi.org/10.1016/j.actatropica.2019.105052

FIGUEIREDO ABF, WERNECK GL, CRUZ MSPE, SILVA JP, ALMEIDA AS. Land use, land cover, and prevalence of canine visceral leishmaniasis in Teresina, Piauí State, Brazil: an approach using orbital remote sensing. Cad Saude Publica. 33(10):e00093516. 2017. DOI: https://doi.org/10.1590/0102-311x00093516

ALMEIDA AS, WERNECK GL. Prediction of high-risk areas for visceral leishmaniasis using socioeconomic indicators and remote sensing data. Int J Health Geogr.13(1):13. 2014. Available from: http://ij-healthgeographics.biomedcentral.com/articles/10.1186/1476-072X-13-13 DOI: https://doi.org/10.1186/1476-072X-13-13

COSTA DNCC, BLANGIARDO M, RODAS LAC, NUNES CM, HIRAMOTO RM et al. Canine visceral leishmaniasis in Araçatuba, state of São Paulo, Brazil, and its relationship with characteristics of dogs and their owners: a cross-sectional and spatial analysis using a geostatistical approach. BMC Veterinary Research. 14:229. 2018. Doi: https://doi.org/10.1186/s12917-018-1550-9 DOI: https://doi.org/10.1186/s12917-018-1550-9

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Published

2022-02-09

How to Cite

1.
Zuque MA da S, Manzini S, Bertozzo TV, Martin MFA, Paixão M dos S, dos Santos WJ, Guiraldi LM, Sanchez GP, Kurokawa CS, Aires IN, Rodrigues NJL, Lucheis SB. OCCURRENCE OF NATURAL INFECTION FOR Leishmania spp. IN THE DOMICILED AND HUMAN CANINE POPULATION OF TRÊS LAGOAS-MS AND SPATIAL ANALYSIS. RVZ [Internet]. 2022 Feb. 9 [cited 2024 Nov. 21];29:1-18. Available from: https://rvz.emnuvens.com.br/rvz/article/view/655

Issue

Vol. 29 (2022)

Section

Original Articles

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