ALTERACIONES SENILES EN EL CEREBRO DE LOS PERROS - ASPECTOS DE IMAGENOLÓGICOS

Autores/as

  • Viviam Rocco Babicsak
  • Luiz Carlos Vulcano

Palabras clave:

cerebro, envejecimiento, perro, resonancia magnética, tomografía computadorizada

Resumen

Estudios relacionados con la verificación de las alteraciones seniles en el cerebro de los perros
se han tornado muy importantes debido a la creciente atención a la salud de los perros de edad
avanzada. La determinación de los hallazgos normales durante el proceso de envejecimiento
permite la identificación de alteraciones durante el mismo. En la condición normal de este
proceso, se puede identificar reducción volumétrica de varias regiones del cerebro asociado a
ensanchamiento de los surcos cerebrales; leve a moderada dilatación de los ventrículos
laterales; disminución en la altura del hipocampo y ensanchamiento de los cuernos
temporales. En pacientes de edad avanzada es posible observar reducción de la atenuación de
la sustancia blanca y gris, así como alteraciones de la intensidad en las imágenes cerebrales
utilizando la tomografía computarizada y la resonancia magnética, respectivamente. En esta
última modalidad de imagen se han descrito áreas hiperintensas en la secuencia T2 e
hipointensas en T1 en el cerebro de seres humanos y caninos, respectivamente. En estos
pacientes, ocurre un aumento de la frecuencia de estas lesiones con el envejecimiento.

Citas

Beason-Held LL, Horwitz B. Aging Brain. In: Ramachandran VS. Encyclopedia of the Human Brain. New York: Academic Press, 2002. p.43-57.

Mosier JE. Effect of ageing on body systems of the dog. Vet Clin North Am Small Anim Pract. 1989;19:1-12.

Tapp PD, Siwak CT. The canine model of human brain aging: cognition, behavior, and neuropathology. In: Conn PM. Handbook of Models for Human Aging. New York: Academic Press, 2006. p.415-434.

Terry RD, DeTeresa R, Hansen LA. Neocortical cell counts in normal human adult aging. Ann Neurol. 1987;21:530-539.

Marner L, Nyengaard JR, Tang Y, Pakkenberg B. Marked loss of myelinated nerve fibers in the human brain with age. J Comp Neurol. 2003;462:144-152.

Kruggel F. MRI-based volumetry of head compartments: normative values of healthy adults. Neuroimage. 2006;30:1-11.

Ge Y, Grossman RI, Babb JS, Rabin ML, Mannon LJ, Kolson DL. Age-related total gray matter and white matter changes in normal adult brain. Part I: volumetric MR imaging analysis. Am J Neuroradiol. 2002;23:1327-1333.

Courchesne E, Chisum HJ, Townsend J, Cowles A, Covington J, Egaas B, et al. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology. 2000;216: 672-682.

Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of aging in 465 normal adult human brains. Neuroimage. 2001;14:21-36.

Sandor T, Albert M, Stafford J, Kemper T. Symmetrical and asymmetrical changes in brain tissue with age as measured on CT scans. Neurobiol Aging. 1990;11:21-27.

Von Braunmühl A. Alterserkrankungen des zentralnervensystems. In: Lubarsch H, Henke F, Rossle R. Handbuch der Speziellen Pathologischen Anatomie and Histologie. Berlin: Springer-Verlag. 1957. p.337-539.

Resnick SM, Pham DL, Kraut MA, Zonderman AB, Davatikos C. Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci. 2003;23:3295-3301.

Petersen RC, Jack Jr CR, Xu YC, Waring, SC, O’Brien PC, Smith GE, et al. Memory and MRI-based hippocampal volumes in aging and AD. Neurology. 2000;54:581-587.

Borràs D, Ferrer I, Pumarola M. Age-related changes in the brain of the dog. Vet Pathol. 1999;36:202-211.

Esiri MM, Hyman BT, Beyreuther K, Masters CL. Aging and dementia. In: Graham DI, Lantos PL. Greenfield’s Neuropathology. 6 ed. London: Arnold, 1997. p. 153-213.

Uchida K, Nakayama H, Goto N. Pathological studies on cerebral amyloid angiopathy, senile plaques and amyloide deposition in visceral organs in aged dogs. J Vet Med Sci. 1991;53:1037-1042.

Head E. Brain aging in dogs: parallels with human brain aging and Alzheimer’s disease. Vet Therapeutics. 2001:2:247-260.

Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging. 2000;21:89-96.

Colle M-A, Hauw J-J, Crespeau F, Uchihara T, Akiyama H, Checler F, et al. Vascular and parenchymal Aβ deposition in the aging dog: correlation with behavior. Neurobiol Aging. 2000;21:695-704.

Prior R, D’Urso DE, Frank R, Prikulis I, Pavlakovic G. Loss of vessel wall viability in cerebral amyloid angiopathy. Neuroreport. 1996;7:562-564.

Su M-Y, Head E, Brooks WM, Wang Z, Muggenburg B, Adam GE, et al. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol Aging. 1998;19:479-485.

Scahill RI, Frost C, Jenkins R, Whitwell JL, Rossor MN, Fox NC. A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch Neurol. 2003;60:989-994.

Pugliese M, Carrasco JP, Gomez-Anson B, Andrade C, Zamora A, Rodríguez MJ, et al. Magnetic resonance imaging of cerebral involutional changes in dogs as markers of aging: an innovative tool adapted from a human visual rating scale. Vet J. 2010;186:166-171.

Szentkuti A, Guderian S, Schiltz K, Kaufmann J, Münte TF, Heinze HJ, et al. Quantitative MR analyses of the hippocampus: unspecific metabolic changes in aging. J Neurol. 2004;251:1345-1353.

Pfefferbaum A, Sullivan EV, Jernigan TL, Zipursky RB, Rosenbloom MJ, Yesavage JA, et al. A quantitative analysis of CT and cognitive measures in normal aging and Alzheimer’s disease. Psychiatry Res. 1990;35:115-136.

Jernigan TL, Archibald SL, Fennema-Notestine C, Gamst AC, Stout JC, Bonner J, et al. Effects of age on tissues and regions of the cerebrum and cerebellum. Neurobiol Aging. 2001;22:581-594.

Walhovd KB, Fjell AM, Reinvang I, Lundervold A, Dale AM, Eilertsen DE, et al. Effects of age on volumes of cortex, white matter and subcortical structures. Neurobiol Aging. 2005;26:1261-1270.

Luft AR, Skalej M, Schulz JB, Welte D, Kolb R, Bürk K, et al. Patterns of age-related shrinkage in cerebellum and brainstem observed in vivo using three-dimensional MRI volumetry. Cereb Cortex. 1999;9:712-721.

Matsumae M, Kikinis R, Mórocz IA, Lorenzo AV, Sándor T, Albert MS, et al. Age-related changes in intracranial compartment volumes in normal adults assessed by magnetic resonance imaging. J Neurosurg. 1996;84:982-991.

Wanifuchi H, Shimizu T, Maruyama T. Age-related changes in the proportion of intracranial cerebrospinal fluid space measured using volumetric computerized tomography scanning. J Neurosurg. 2002;97:607–610.

Su M-Y, Tapp PD, Vu L, Chen Y-F, Chu Y, Muggenburg B, et al. A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:389-397.

LeMay M. Radiologic changes of the aging brain and skull. Am J Roentgenol. 1984;143:383-389.

Gonzáles-Soriano J, García M., Contreras-Rodriguez J, Martínez-Saintz P, Rodrigués-Veiga E. Age-related changes in the ventricular system of the dog brain. Ann Anat. 2001;183:283-291.

Meyer JS, Takashima S, Terayama Y, Obara K, Muramatsu K, Weather S. CT changes associated with normal aging of the human brain. J Neurol Sci. 1994;123:200-208.

Masliah E, Mallory M, Hanson L, DeTeresa R, Terry RD. Quantitative synaptic alteration m the human neocortex during normal aging. Neurol. 1993;43:192-197.

Terayama Y, Meyer JS, Takashima S, Obara K, Weathers S. Comparisons of polio-araiosis and leuko-araiosis in dementias of ischemic vascular and Alzheimer types. J. Stroke Cerebrovasc Dis. 1993;3:267-275.

Meyer JS, Kawamura J, Terayama Y. White matter lesions in the elderly. J Neurol Sci. 1992;110:1-7.

Awad IA, Spetzler RF, Hodak CA, Awad CA, Carey R. Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors. Stroke. 1986;17:1084-1089.

Fuster JM. Frontal lobe and cognitive development. J Neurocytol. 2002;31:319-333.

Publicado

2023-04-19

Cómo citar

1.
Babicsak VR, Vulcano LC. ALTERACIONES SENILES EN EL CEREBRO DE LOS PERROS - ASPECTOS DE IMAGENOLÓGICOS . RVZ [Internet]. 19 de abril de 2023 [citado 14 de mayo de 2024];20(2):9-20. Disponible en: https://rvz.emnuvens.com.br/rvz/article/view/1479

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