Continuous infusion of two doses of fentanyl associated with lidocaine and ketamine for female dogs anesthetized with sevoflurane and undergoing elective ovaryohysterectomy

Authors

  • Samuel Monzem Universidade Federal de Mato Grosso - Faculdade de Medicina Veterinária
  • Lianna Ghisi Gomes Universidade Federal de Mato Grosso - Faculdade de Medicina Veterinária
  • Andresa de Cássia Martini, Dr Universidade Federal de Mato Grosso - Faculdade de Medicina Veterinária
  • Dábila Araújo Sonegô Universidade Federal de Mato Grosso - Faculdade de Medicina Veterinária
  • Daiana Cristina Winter Universidade Federal de Mato Grosso - Faculdade de Medicina Veterinária
  • Paulo Roberto Spiller Complexo Veterinário da Universidade Federal de Roraima (CVET-UFRR)
  • Luciana Dambrósio Guimarães Universidade Federal de Mato Grosso - Faculdade de Medicina Veterinária

DOI:

https://doi.org/10.35172/rvz.2019.v26.191

Keywords:

antagonist NMDA, dog, local anesthesic, opioide.

Abstract

The aim of this study was to evaluate the cardiorespiratory effects of two doses of fentanyl associated with lidocaine and ketamine in canine females anesthetized with sevoflurane and submitted to elective ovariohysterectomy. 18 animals were randomly assigned to two groups. Group A (GA) animals received a loading dose intravenously of fentanyl 0.0018 mg/kg and those of group B (GB) 0.0036 mg/kg, both associated with lidocaine 3 mg/kg and ketamine 0, 6 mg/kg. Immediately after the loading dose, induction with propofol was realized followed by continuous infusion (CI) of fentanyl at the dose of 0.0018 mg/kg/h for GA and 0.0036 mg/kg/h for GB, both associated to 3 and 0.6 mg/kg/h of lidocaine and ketamine. The anesthesia was maintained with sevoflurane diluted in 100% oxygen at 1.5% by a calibrated vaporizer that was adjusted for the maintenance of the surgical anesthetic plane. The animals were placed in dorsal decubitus position and remained under spontaneous ventilation. Was evaluated the baseline values ​​(T0), after induction (T1) and 5 (T5), 20 (T20) and 35 (T35) minutes of following parameters: heart rate (HR), respiratory rate (f), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MAP), oxygen saturation in hemoglobin (SatO2), partial carbon dioxide (EtCO2) pressure and expired sevoflurane (EtSevo). Statistical analysis was performed through analysis of variance followed by the Scott-knott test. Differences were considered significant when P < 0.05. HR decreased after 20 minutes of CI and f, SBP, DBP and MAP decreased after anesthetic induction. These differences were not clinically relevant and the values ​​remained within the physiological limit. It can be concluded that the two doses of continuous infusion of fentanyl produced cardiovascular and respiratory stability, besides allowing the reduction of the sevoflurane requirement for elective ovariohysterectomy.

 

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Published

2019-11-25

How to Cite

1.
Monzem S, Gomes LG, Martini A de C, Sonegô DA, Winter DC, Spiller PR, Guimarães LD. Continuous infusion of two doses of fentanyl associated with lidocaine and ketamine for female dogs anesthetized with sevoflurane and undergoing elective ovaryohysterectomy. RVZ [Internet]. 2019 Nov. 25 [cited 2024 Jul. 22];26:1-7. Available from: https://rvz.emnuvens.com.br/rvz/article/view/191

Issue

Vol. 26 (2019)

Section

Original Articles

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Licença Creative Commons
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.

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