FAMILY RENAL AMYLOIDOSIS IN TWO SHAR-PEI DOGS

Authors

  • Felipe Gaia de Sousa Federal University of Minas Gerais https://orcid.org/0000-0002-5078-7820
  • Suzane Lilian Beier Federal University of Minas Gerais https://orcid.org/0000-0002-7352-5145
  • Juliana dos Santos Masiero Federal University of Minas Gerais
  • Fabiana Silva Fádel Queiroz Federal University of Minas Gerais

DOI:

https://doi.org/10.35172/rvz.2024.v31.1557

Keywords:

chronic kidney disease, glomerulopathies, heredity, amyloid protein

Abstract

Familial renal amyloidosis is an uncommon disease in dogs, which affects the kidneys and is associated with abnormal accumulation of amyloid proteins, capable of promoting progressive organic damage with impairment of functionality. Characterized by the presence of glomerular proteinaceous content, amyloidosis is often associated with renal failure, with the presence of varied clinical signs, being a serious and complex condition. This article aims to describe the clinical, laboratory, imaging and histopathological findings of familial amyloidosis in two Shar-pei dogs. The animals were directly related and evidenced signs of tiredness, prostration and progressive weight loss. Clinical, laboratory and ultrasonographic evidence suggested the presence of glomerulonephropathy, which was confirmed by histopathological examination. The two dogs, given the severity of the condition, died. Histopathological analysis showed deposition of fibrillar proteinaceous material in the glomerular and tubular region, as well as lymphoplasmocytic infiltrate, characteristic of renal amyloidosis. It is essential to remember that familial renal amyloidosis in dogs is a complex disease and that the origins must be investigated. The treatment is challenging, given the lack of a defined therapeutic management for the disease, which is often ineffective. Empathy and care in managing this condition can help improve the patient's quality of life and provide comfort to the owner during this challenging process.

Author Biographies

Felipe Gaia de Sousa, Federal University of Minas Gerais

Federal University of Minas Gerais

Suzane Lilian Beier, Federal University of Minas Gerais

Federal University of Minas Gerais

Juliana dos Santos Masiero, Federal University of Minas Gerais

Federal University of Minas Gerais

Fabiana Silva Fádel Queiroz, Federal University of Minas Gerais

Federal University of Minas Gerais

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Published

2024-01-31

How to Cite

1.
Gaia de Sousa F, Beier S, Masiero J, Queiroz F. FAMILY RENAL AMYLOIDOSIS IN TWO SHAR-PEI DOGS . RVZ [Internet]. 2024 Jan. 31 [cited 2024 May 16];31:1-9. Available from: https://rvz.emnuvens.com.br/rvz/article/view/1557

Issue

Vol. 31 (2024): Veterinária e Zootecnia

Section

Case Reports

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Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional.

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